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Ibritumomab Side Effects

For the Consumer

Applies to ibritumomab: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by ibritumomab. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking ibritumomab, check with your doctor or nurse immediately:

More common:
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • cough or hoarseness
  • coughing up blood
  • difficulty with breathing or swallowing
  • dizziness
  • fever or chills
  • headache
  • increased menstrual flow or vaginal bleeding
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lower back or side pain
  • noisy breathing
  • nosebleeds
  • painful or difficult urination
  • pale skin
  • paralysis
  • pinpoint red spots on the skin
  • prolonged bleeding from cuts
  • red or dark brown urine
  • red stools
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wheezing
Less common:
  • Bloody nose that does not stop after pinching the nose together and holding it for 5 to 10 minutes
  • bluish lips or skin
  • chest pain or discomfort
  • confusion
  • diarrhea
  • fainting
  • fast heartbeat
  • hives
  • itching
  • lightheadedness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid, shallow breathing
  • skin rash
  • small red or purple spots on the skin
  • unusual vaginal bleeding
  • vomiting blood or material that looks like coffee grounds
  • Agitation
  • anxiety
  • back pain
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, or warmth at the injection site
  • blurred vision
  • coma
  • drowsiness
  • fast, pounding, or irregular heartbeat or pulse
  • hallucinations
  • inability to speak
  • irritability
  • mood or mental changes
  • nausea
  • redness of the skin
  • seizures
  • severe headache
  • slurred speech
  • stiff neck
  • temporary blindness
  • vomiting
  • weakness in the arm or leg on one side of the body, sudden and severe
  • welts
Incidence not known:
  • Blistering, peeling, or loosening of the skin
  • cracks in the skin
  • joint or muscle pain
  • loss of heat from the body
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • scaly skin
  • skin blisters

Minor Side Effects

Some of the side effects that can occur with ibritumomab may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Abdominal or stomach pain
  • bruising
  • constipation
  • difficult or labored breathing
  • difficulty with moving
  • faintness or lightheadedness when getting up from a lying or sitting position
  • fear
  • feeling of warmth
  • full or bloated feeling or pressure in the stomach
  • joint pain
  • lack or loss of strength
  • large, flat, blue or purplish patches in the skin
  • loss of appetite
  • muscle aching or cramping
  • muscle pain or stiffness
  • nervousness
  • pain
  • rash
  • redness of the face, neck, arms and occasionally, upper chest
  • runny nose
  • sleeplessness
  • sneezing
  • stuffy nose
  • sudden or increased sweating
  • swelling of the abdominal or stomach area
  • swelling of the hands, ankles, feet, or lower legs
  • swollen joints
  • throat irritation
  • trouble with sleeping
  • unable to sleep
  • weight loss
Less common:
  • Acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • stomach discomfort, upset, or pain
  • swelling or redness in the joints

For several months after receiving this therapy, it may still produce some side effects that need attention. During this period of time check with your doctor immediately if you notice any of the following:

  • Bleeding gums
  • bone pain
  • headache, sudden and severe
  • inability to speak
  • increased menstrual flow or vaginal bleeding
  • red or black, tarry stools
  • red or dark brown urine
  • temporary blindness

For Healthcare Professionals

Applies to ibritumomab: intravenous kit


Common (1% to 10%): Hypertension[Ref]


Common (1% to 10%): Night sweats, petechiae, pruritus, rash
Postmarketing reports: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous dermatitis, exfoliative dermatitis[Ref]


Very common (10% or more): Nausea, abdominal pain, diarrhea[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Very common (10% or more): Thrombocytopenia, neutropenia, anemia, leukopenia, lymphopenia
Common (1% to 10%): Ecchymosis
Frequency not reported: Cytopenias[Ref]


Postmarketing reports: Infusion site erythema, ulceration following extravasation[Ref]


Common (1% to 10%): Anorexia[Ref]


Very common (10% or more): Myalgia[Ref]

Nervous system

Common (1% to 10%): Dizziness[Ref]


Frequency not reported: Secondary malignancy[Ref]


Very common (10% or more): Fatigue, asthenia, pyrexia, serious and life threatening infections
Common (1% to 10%): Influenza-like illness
Uncommon (0.1% to 1%): Antibody formation
Postmarketing reports: Radiation injury[Ref]


Very common (10% or more): Nasopharyngitis, cough
Common (1% to 10%): Pharyngolaryngeal pain, epistaxis, bronchitis, rhinitis, sinusitis[Ref]


1. "Product Information. In-111 Zevalin (ibritumomab)." IDEC Pharmaceuticals Corporation, San Diego, CA.

Not all side effects for ibritumomab may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.