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Ibritumomab Tiuxetan

Generic Name: Ibritumomab Tiuxetan (ib ri TYOO mo mab tye UX e tan)
Brand Name: Zevalin Y-90

Medically reviewed by Drugs.com. Last updated on Sep 10, 2020.

Warning

  • This medicine is used with a drug called rituximab. Talk with the doctor about the risks and side effects that may happen.
  • This medicine may lower the ability of the bone marrow to make blood cells that the body needs. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. If you have questions, talk with the doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Uses of Ibritumomab Tiuxetan:

  • It is used to treat a type of lymphoma.

What do I need to tell my doctor BEFORE I take Ibritumomab Tiuxetan?

  • If you are allergic to mouse proteins or yttrium chloride, talk with the doctor.
  • If you are allergic to ibritumomab tiuxetan; any part of ibritumomab tiuxetan; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you are taking any drugs that may raise the chance of bleeding. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
  • If you are breast-feeding. Do not breast-feed while you take ibritumomab tiuxetan or within 6 months after your last dose.

This is not a list of all drugs or health problems that interact with ibritumomab tiuxetan.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take ibritumomab tiuxetan with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Ibritumomab Tiuxetan?

  • Tell all of your health care providers that you take ibritumomab tiuxetan. This includes your doctors, nurses, pharmacists, and dentists.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • Talk with your doctor before getting any vaccines while you take ibritumomab tiuxetan and after you stop taking it. Vaccine use with ibritumomab tiuxetan may either raise the chance of an infection or make the vaccine not work as well. Talk with your doctor.
  • This medicine is radioactive. You will need to follow what the doctor has told you to lessen being exposed to ibritumomab tiuxetan.
  • If you have upset stomach, throwing up, diarrhea, or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • Rarely, a bone marrow problem called myelodysplastic syndrome (MDS) and a type of leukemia have happened in patients treated with this drug. Sometimes, this has been deadly.
  • This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child.
  • This medicine may cause harm to an unborn baby. A pregnancy test will be done before you start ibritumomab tiuxetan to show that you are NOT pregnant.
  • Women must use birth control while taking ibritumomab tiuxetan and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
  • Men with a partner who may get pregnant must use birth control while taking ibritumomab tiuxetan and for some time after the last dose. Ask your doctor how long to use birth control. If your partner gets pregnant, call the doctor right away.

How is this medicine (Ibritumomab Tiuxetan) best taken?

Use ibritumomab tiuxetan as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given into a vein for a period of time.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
  • Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
  • Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Chest pain or pressure.
  • Shortness of breath.
  • A heartbeat that does not feel normal.
  • Pale skin.
  • Pinpoint red spots on the skin.
  • This medicine may cause tissue damage if the drug leaks from the vein. Tell your nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body.

What are some other side effects of Ibritumomab Tiuxetan?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling dizzy, tired, or weak.
  • Stomach pain or diarrhea.
  • Upset stomach.
  • Flu-like signs.
  • Muscle pain.
  • Not hungry.
  • Night sweats.
  • Nose or throat irritation.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Ibritumomab Tiuxetan?

  • If you need to store ibritumomab tiuxetan at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about ibritumomab tiuxetan, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.