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Homatropine ophthalmic Side Effects

For the Consumer

Applies to homatropine ophthalmic: ophthalmic solution

Side effects include:

Elevated IOP, transient stinging, burning. With prolonged administration, local irritation (characterized by follicular conjunctivitis, vascular congestion, edema, exudate, and eczematoid dermatitis ), thirst, dry mouth, increased light sensitivity of eyes.

For Healthcare Professionals

Applies to homatropine ophthalmic: compounding powder, ophthalmic solution


The most frequently reported side effects were transient stinging/burning upon instillation and increased sensitivity to light.[Ref]


Common (1% to 10%): Transient burning, transient stinging, increased sensitivity to light
Uncommon (0.1% to 1%): Eye irritation
Rare (0.01% to 0.1%): Local irritation, vascular congestion, edema, exudates, eczematoid dermatitis, follicular conjunctivitis
Postmarketing reports: Conjunctivitis, photophobia, mydriasis prolonged, eye pain, eye edema, eye discharge, eye irritation, ocular hyperemia[Ref]


Rare (0.01% to 0.1%): Thirst, dryness of mouth
Frequency not reported: Abdominal distention infants, gastrointestinal motility diminished, salivary secretion decreased, sweat gland secretion decreased[Ref]

Nervous system

Frequency not reported: Ataxia, incoherent speech, hyperactivity, seizure, unusual drowsiness
Postmarketing reports: Somnolence[Ref]


Frequency not reported: Restlessness, hallucination, disorientation, failure to recognize people
Postmarketing reports: Confusion[Ref]


Frequency not reported: Urinary retention[Ref]


Frequency not reported: Secretion decreased in pharynx/bronchi/nasal passages, rapidly progressive respiratory depression[Ref]


Frequency not reported: Hyperpyrexia[Ref]


Frequency not reported: Tachycardia, vasodilation, hypotension
Postmarketing reports: Heart rate increased[Ref]


Frequency not reported: Skin rash[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Homatropine Hydrobromide (homatropine ophthalmic)." OCuSOFT, Richmond, TX.

Some side effects of homatropine ophthalmic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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