Homatropine Ophthalmic Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 22, 2024.

Applies to homatropine ophthalmic: ophthalmic solution.

Side effects include:

Elevated IOP, transient stinging, burning. With prolonged administration, local irritation (characterized by follicular conjunctivitis, vascular congestion, edema, exudate, and eczematoid dermatitis ), thirst, dry mouth, increased light sensitivity of eyes.

For healthcare professionals

Applies to homatropine ophthalmic: compounding powder, ophthalmic solution.

General adverse events

The most frequently reported side effects were transient stinging/burning upon instillation and increased sensitivity to light.^[Ref]

Ocular

• Common (1% to 10%): Transient burning, transient stinging, increased sensitivity to light
• Uncommon (0.1% to 1%): Eye irritation
• Rare (0.01% to 0.1%): Local irritation, vascular congestion, edema, exudates, eczematoid dermatitis, follicular conjunctivitis
• Postmarketing reports: Conjunctivitis, photophobia, mydriasis prolonged, eye pain, eye edema, eye discharge, eye irritation, ocular hyperemia^[Ref]

Gastrointestinal

• Rare (0.01% to 0.1%): Thirst, dryness of mouth
• Frequency not reported: Abdominal distention infants, gastrointestinal motility diminished, salivary secretion decreased, sweat gland secretion decreased^[Ref]

Nervous system

• Frequency not reported: Ataxia, incoherent speech, hyperactivity, seizure, unusual drowsiness
• Postmarketing reports: Somnolence^[Ref]

Psychiatric

• Frequency not reported: Restlessness, hallucination, disorientation, failure to recognize people
• Postmarketing reports: Confusion^[Ref]

Genitourinary

• Frequency not reported: Urinary retention^[Ref]

Respiratory

• Frequency not reported: Secretion decreased in pharynx/bronchi/nasal passages, rapidly progressive respiratory depression^[Ref]

Other

• Frequency not reported: Hyperpyrexia^[Ref]

Cardiovascular

• Frequency not reported: Tachycardia, vasodilation, hypotension
• Postmarketing reports: Heart rate increased^[Ref]

Dermatologic

• Frequency not reported: Skin rash^[Ref]

See also:

Further information

Homatropine ophthalmic side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer