Herceptin Hylecta Side Effects

Generic name: hyaluronidase / trastuzumab

Medically reviewed by Drugs.com. Last updated on Feb 16, 2025.

Note: This document provides detailed information about Herceptin Hylecta Side Effects associated with hyaluronidase / trastuzumab. Some dosage forms listed on this page may not apply specifically to the brand name Herceptin Hylecta.

Applies to hyaluronidase / trastuzumab: subcutaneous solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Receiving this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for 7 months after the last dose. If you think you have become pregnant while receiving the medicine, tell your doctor right away.

Your doctor may test your heart before you start receiving trastuzumab and hyaluronidase-oysk combination injection and while you are getting treatments with this medicine. Contact your doctor right away if you experience any chest pain, increased coughing, trouble with breathing, a sudden difficulty with breathing at night, rapid weight gain, or abnormal swelling in your ankles or legs. These could be symptoms of a serious heart problem.

Serious lung or breathing problems may occur after you receive this medicine. Call your doctor right away if have changes in your breathing, chest tightness, or any type of breathing problem.

This medicine can temporarily lower the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Do not receive an anthracycline medicine for up to 7 months after stopping treatment with this medicine.

Serious side effects of Herceptin Hylecta

Along with its needed effects, hyaluronidase / trastuzumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hyaluronidase / trastuzumab:

Other side effects of Herceptin Hylecta

Some side effects of hyaluronidase / trastuzumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to hyaluronidase / trastuzumab: subcutaneous solution.

Hematologic adverse events

• Very common (10% or more): Neutropenia (44%), anemia (12%), leukopenia (11%)
• Common (1% to 10%): Febrile neutropenia^[Ref]

Hypersensitivity

• Very common (10% or more): Hypersensitivity (10%)^[Ref]

Immunologic

• Very common (10% or more): Infection (20%), influenza syndrome (10%)
• Common (1% to 10%): Viral infection
• Postmarketing reports: Immune thrombocytopenia^[Ref]

Local

• Very common (10% or more): Injection site reaction/complication (e.g., joint pain, bruising, dermatitis, discoloration, discomfort, erythema, extravasation, fibrosis, hematoma, hemorrhage, hypersensitivity, induration, inflammation, irritation, macule, mass, nodule, edema, pallor, paresthesia, pruritus, rash, reaction, swelling, ulcer, vesicles, warmth) (10%)^[Ref]

Musculoskeletal

• Very common (10% or more): Myalgia (21%), arthralgia (18%), asthenia (12%), back pain (11%), pain in extremity (10%)
• Common (1% to 10%): Bone pain^[Ref]

Metabolic

• Very common (10% or more): Decreased appetite (20%)^[Ref]

Psychiatric

• Very common (10% or more): Insomnia (14%)
• Common (1% to 10%): Depression^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Hepatic

• Common (1% to 10%): Liver function abnormal^[Ref]

Oncologic

• Postmarketing reports: Tumor lysis syndrome (TLS)

Respiratory

• Very common (10% or more): Upper respiratory tract infection (24%), cough (22%), rhinitis (14%), pharyngitis (12%)
• Common (1% to 10%): Dyspnea, epistaxis, nasal inflammation/discomfort, sinusitis^[Ref]

Other

• Very common (10% or more): Fatigue (46%), chills (32%), edema (14%), pyrexia (13%)
• Common (1% to 10%): Pain
• Postmarketing reports: Oligohydramnios or oligohydramnios sequence (including pulmonary hypoplasia, skeletal abnormalities, and neonatal death)^[Ref]

Nervous system

• Very common (10% or more): Peripheral neuropathy (20%), headache (17%), dizziness (13%), dysgeusia (10%)
• Common (1% to 10%): Paresthesia, peripheral neuritis, neuropathy^[Ref]

Renal

• Postmarketing reports: Glomerulopathy^[Ref]

Cardiovascular

• Very common (10% or more): Flushing (14%)
• Common (1% to 10%): Hypertension, arrhythmia, ejection fraction decreased, left ventricular dysfunction, tachycardia, congestive heart failure^[Ref]

Dermatologic

• Very common (10% or more): Alopecia (63%), rash (26%), nail disorder (14%)
• Common (1% to 10%): Pruritus, nail discoloration, erythema, herpes simplex, acne^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (49%), diarrhea (34%), vomiting (23%), stomatitis (21%), abdominal pain (14%), dyspepsia (11%), mucosal inflammation (10%)
• Common (1% to 10%): Constipation, stomatitis^[Ref]

See also:

Frequently asked questions

• What is Herceptin? Is Herceptin a chemo drug? How does it work?
• What is the difference between Herceptin and Herceptin Hylecta?
• Does Herceptin (trastuzumab) stop menstrual periods?
• Do Herceptin (trastuzumab) injections hurt?
• How is Herceptin Injection and Herceptin Hylecta administered?

Further information

Herceptin Hylecta side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer