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H.P. Acthar Gel Side Effects

Generic Name: corticotropin

Note: This document contains side effect information about corticotropin. Some of the dosage forms listed on this page may not apply to the brand name H.P. Acthar Gel.

For the Consumer

Applies to corticotropin: injection gel/jelly

Along with its needed effects, corticotropin (the active ingredient contained in H.P. Acthar Gel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking corticotropin:

More Common

  • Backache
  • blurred vision
  • body aches or pain
  • chest pain
  • cough
  • difficulty with breathing
  • dizziness
  • ear congestion
  • earache
  • facial hair growth in females
  • fever or chills
  • fractures
  • full or round face, neck, or trunk
  • headache
  • increased thirst or urination
  • irritability
  • loss of sexual desire or ability
  • loss of voice
  • menstrual irregularities
  • muscle wasting
  • nasal congestion
  • nervousness
  • pounding in the ears
  • redness or swelling in the ear
  • runny nose
  • shortness of breath
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • tightness in the chest
  • troubled breathing
  • unusual tiredness or weakness
  • wheezing
  • white patches in the mouth or throat or on the tongue
  • white patches with diaper rash

Less Common

Incidence Not Known

  • Accumulation of pus
  • bruising
  • bulging soft spot on the head of an infant
  • change in the ability to see colors, especially blue or yellow
  • cold, clammy skin
  • confusion
  • decreased range of motion
  • decreased urine output
  • dilated neck veins
  • extreme fatigue
  • eyeballs bulge out of eye sockets
  • fast, weak pulse
  • full or bloated feeling
  • heartburn
  • insomnia
  • irregular breathing
  • irregular heartbeat
  • joint pain
  • large, flat, blue, or purplish patches in the skin
  • lightheadedness
  • limp
  • loss of appetite
  • nausea and vomiting
  • pressure in the stomach
  • severe headache
  • small red or purple spots on the skin
  • sweating
  • swelling of abdominal or stomach area
  • swelling of the face, fingers, feet, or lower legs
  • swollen, red, or tender area of infection
  • trouble healing
  • weight gain
  • wheezing

Incidence not known-For adults only

  • Bloating
  • chills
  • confusion
  • constipation
  • coughing up blood
  • darkened urine
  • fast heartbeat
  • fever
  • headache
  • headache, sudden and severe
  • increased sweating
  • indigestion
  • loss of appetite
  • pain in the muscles
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • redness of the face
  • skin rash
  • unusual weight loss
  • weakness
  • yellow eyes or skin

Incidence not known-For infants only

  • Decreased carbohydrate tolerance
  • hypokalemic alkalosis
  • reversible brain shrinkage

Some side effects of corticotropin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

  • Increased or decreased appetite

Incidence Not Known

  • Increased hair growth, especially on the face
  • menstrual changes
  • muscle weakness

Incidence not known-For adults only

  • Feeling of constant movement of self or surroundings
  • sensation of spinning
  • thinning of the skin

For Healthcare Professionals

Applies to corticotropin: injectable powder for injection, injectable solution


Very Common (10% or more): Hypertension

Common (1% to 10%): Cardiac hypertrophy

Frequency not reported: Fluid retention

Postmarketing reports: Necrotizing angitis (adults only), congestive heart failure[Ref]


Very common (10% or more): Acne

Common (1% to 10%): Rash

Postmarketing reports: Skin thinning (adults only), facial erythema, increased sweating (adults only)[Ref]


Very common (10% or more): Cushingoid

Common (1% to 10%): Cushingoid

Postmarketing reports: Decreased carbohydrate tolerance (infants only), hirsutism[Ref]


Very common (10% or more): Diarrhea

Common (1% to 10%): Constipation, diarrhea, vomiting

Postmarketing reports: Pancreatitis (adults only), abdominal distention, ulcerative esophagitis[Ref]


Postmarketing reports: Allergic responses presenting as dizziness, nausea, and shock (adult only).[Ref]


Common (1% to 10%): Increased appetite, decreased appetite, weight gain

Frequency not reported: Alteration in glucose tolerance

Postmarketing reports: Hypokalemic alkalosis (infants only)[Ref]


Postmarketing reports: Muscle weakness, vertebral compression fractures (infants only)[Ref]

Nervous system

Very Common (10% to more): Convulsions

Common (1% to 10%): Convulsions

Postmarketing reports: Headache (adults only), vertigo (adults only), subdural hematoma, intracranial hemorrhage (adults only), reversible brain shrinkage (secondary to hypertension in infants only)[Ref]


Very Common (10% or more): Infection

Common (1% or 10%): Pyrexia, candidiasis, otitis media[Ref]


Very common (10% or more): Irritability

Common (1% to 10%): Irritability

Frequency not reported: Behavioral and mood changes[Ref]


Common (1% or 10%): Nasal congestion, pneumonia, upper respiratory infections.[Ref]


1. "Product Information. Acthar (corticotropin)." Rhone-Poulenc Rorer, Collegeville, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.