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Gammagard Liquid Side Effects

Generic name: immune globulin intravenous and subcutaneous

Medically reviewed by Last updated on Mar 25, 2024.

Note: This document contains side effect information about immune globulin intravenous and subcutaneous. Some dosage forms listed on this page may not apply to the brand name Gammagard Liquid.

Applies to immune globulin intravenous and subcutaneous: injectable solution.


This medicine can cause blood clots. The risk is highest in older adults or in people who have had blood clots, heart problems, or blood circulation problems. Blood clots are also more likely during long-term bedrest, while using birth control pills or hormone replacement therapy, or while having a central intravenous (IV) catheter in place.

Call your doctor at once if you have chest pain, trouble breathing, fast heartbeats, numbness or weakness, or swelling and warmth or discoloration in an arm or leg.

This medicine can also harm your kidneys, especially if you have kidney disease or if you also use certain medicines. Tell your doctor right away if you have signs of kidney problems, such as swelling, rapid weight gain, and little or no urination.

Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, difficulty breathing; dizziness, feeling like you might pass out; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver if you feel light-headed, itchy, chilled, sweaty, or have chest discomfort, fast heartbeats, severe headache, or pounding in your neck or ears.

Call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to immune globulin intravenous and subcutaneous: injectable solution.


The most common adverse events were headache and injection/infusion site reactions.[Ref]


Very common (10% or more): Infusion site reaction (75%)

Common (1% to 10%): Injection site reaction

Frequency not reported: Hives/urticaria, itching

Nervous system

Very common (10% or more): Headache (58%)

Common (1% to 10%): Dizziness

Postmarketing reports: Aseptic meningitis, coma, loss of consciousness, seizures/convulsions, tremor[Ref]


Very common (10% or more): Ecchymosis/purpura (40%), petechiae (21%), rash (10%)

Common (1% to 10%): Pruritus, urticaria

Frequency not reported: Hives

Postmarketing reports: Stevens-Johnson syndrome, epidermolysis, erythema multiforme, bullous dermatitis[Ref]


Very common (10% or more): Hemorrhage (all systems) (29%), thrombocytopenia (15%)

Common (1% to 10%): Anemia

Uncommon (0.1% to 1%): Coombs negative hypochromic anemia, autoimmune pure red cell aplasia, exacerbation of autoimmune pure red cell aplasia

Postmarketing reports: Hemolytic anemia, pancytopenia, leukopenia, hemolysis, positive direct antiglobulin (Coombs test)[Ref]


Very common (10% or more): Diarrhea (28%), nausea (21%), vomiting (21%)

Common (1% to 10%): Abdominal pain, dyspepsia[Ref]


Very common (10% or more): Cough increased (54%), rhinitis (51%), pharyngitis (41%), asthma (29%), epistaxis (23%)

Common (1% to 10%): Influenza, flu syndrome, sinusitis

Postmarketing reports: Apnea, acute respiratory distress syndrome (ARDS), transfusion related acute lung injury (TRALI), cyanosis, hypoxemia, pulmonary edema, dyspnea, bronchospasm[Ref]


Common (1% to 10%): Hypertension

Frequency not reported: Myocarditis

Postmarketing reports: Cardiac arrest, thromboembolism, vascular collapse, hypotension[Ref]


Very common (10% or more): Elevated ALT (18%), alkaline phosphatase elevated (13%)

Common (1% to 10%): AST elevated, low alkaline phosphatase

Postmarketing reports: Hepatic dysfunction[Ref]


Very common (10% or more): Fever (28%), ear pain (18%), accidental injury (13%), asthenia (10%)

Common (1% to 10%): Fatigue

Postmarketing reports: Rigors


Common (1% to 10%): Arthralgia, back pain, neck pain

Uncommon (0.1% to 1%): Severe chills[Ref]


Frequency not reported: Anxiety


1. (2011) "Product Information. Gamunex-C (immune globulin intravenous and subcutaneous)." Talecris Biotherapeutics

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.