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Flunisolide Side Effects

For the Consumer

Applies to flunisolide: inhalation aerosol liquid, inhalation aerosol powder

In addition to its needed effects, some unwanted effects may be caused by flunisolide. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking flunisolide:

More common:
  • Body aches or pain
  • congestion
  • cough
  • dryness or soreness of the throat
  • fever
  • headache
  • hoarseness
  • pain or tenderness around the eyes and cheekbones
  • shortness of breath or troubled breathing
  • sneezing
  • stuffy or runny nose
  • tender, swollen glands in the neck
  • tightness of the chest or wheezing
  • trouble with swallowing
  • voice changes
Less common:
  • Bladder pain
  • blistering, peeling, or loosening of the skin
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody nose
  • bloody or cloudy urine
  • blurred vision
  • chest pain
  • chills
  • cough producing mucus
  • diarrhea
  • difficult, burning, or painful urination
  • dizziness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • hives
  • itching
  • joint or muscle pain
  • lower back or side pain
  • nervousness
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • red, irritated eyes
  • skin rash
  • slow heartbeat
  • sore mouth or tongue
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • swelling
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
Incidence not known:
  • Creamy white, curd-like patches in the mouth or throat
  • darkening of the skin
  • discouragement
  • fainting
  • feeling sad or empty
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • loss of strength or energy
  • muscle weakness
  • nausea
  • pain when eating or swallowing
  • trouble concentrating
  • trouble sleeping
  • vomiting

Minor Side Effects

Some of the side effects that can occur with flunisolide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Abdominal or stomach fullness
  • acid or sour stomach
  • appetite changes
  • bad, unusual, or unpleasant (after) taste
  • belching
  • blemishes on the skin
  • burning, dry, or itching eyes
  • change in taste
  • constipation
  • cramps
  • difficulty with moving
  • discharge or excessive tearing
  • dizziness or lightheadedness
  • ear pain
  • fear
  • feeling of constant movement of self or surroundings
  • gas
  • headache, severe and throbbing
  • heartburn
  • heavy bleeding
  • indigestion
  • irritability
  • itching of the vagina or genital area
  • loss of smell or taste
  • muscle aching or cramping
  • muscle stiffness
  • pain during sexual intercourse
  • pain in the neck
  • pimples
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • restlessness
  • sensation of spinning
  • shakiness
  • skin rash, encrusted, scaly, and oozing
  • stomach discomfort, upset, or pain
  • swollen joints
  • thick, white vaginal discharge with no odor or with a mild odor
  • trouble sitting still
  • trouble sleeping
  • upset stomach

For Healthcare Professionals

Applies to flunisolide: compounding powder, inhalation aerosol, inhalation aerosol with adapter


The most commonly reported adverse reactions include pharyngitis, rhinitis, headache, sinusitis, and increased cough.[Ref]


Very common (10% or more): Pharyngitis (up to 17.5%), rhinitis (up to 15.7%)
Common (1% to 10%): Increased cough, sinusitis, epistaxis, bronchitis, laryngitis, voice alteration, cold symptoms, nasal congestion, sinus drainage, sinus infection, sneezing, sputum, wheezing, bronchospasm, dyspnea, head stuffiness, nasal irritation, sinus discomfort, sore throat, dry throat[Ref]


Common (1% to 10%): Vomiting, dyspepsia, abdominal pain, diarrhea, gastroenteritis, nausea, oral moniliasis, upset stomach, heartburn, constipation, gas, abdominal fullness, glossitis, mouth irritation, phlegm[Ref]

Nervous system

Very common (10% or more): Headache (up to 13.8%)
Common (1% to 10%): Migraine, taste perversion, weakness, numbness, hyperactivity[Ref]


Common (1% to 10%): Neck pain, myalgia
Frequency not reported: Decreased bone mineral density; reduction in growth velocity[Ref]


Common (1% to 10%): Blurred vision, eye discomfort, eye infection
Frequency not reported: Glaucoma, increased intraocular pressure, cataracts[Ref]


Common (1% to 10%): Erythema multiforme, sweating, eczema, pruritus, acne, urticaria


Common (1% to 10%): Chest pain, edema, palpitations, tachycardia, hypertension[Ref]


Common (1% to 10%): Urinary tract infection, dysmenorrhea, vaginitis[Ref]


Common (1% to 10%): Enlarged lymph nodes, capillary fragility[Ref]


Common (1% to 10%): Allergic reaction[Ref]


Common (1% to 10%): Decreased appetite, increased appetite, weight gain[Ref]


Common (1% to 10%): Ear pain, chills, malaise, vertigo, fatigue, loss of smell, ear infection[Ref]


Common (1% to 10%): Insomnia, irritability, shakiness, anxiety, depression, moodiness, hypoactivity[Ref]


1. "Product Information. Aerospan (flunisolide)." Meda Pharmaceuticals, Somerset, NJ.

Not all side effects for flunisolide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.