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Filgrastim Side Effects

In Summary

Commonly reported side effects of filgrastim include: hyperuricemia, increased lactate dehydrogenase, increased leukocyte alkaline phosphatase, increased serum alkaline phosphatase, ostealgia, and thrombocytopenia. Other side effects include: arthralgia, headache, myalgia, and pruritus. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to filgrastim: injection injectable, injection solution

Along with its needed effects, filgrastim may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking filgrastim:

More Common

  • Abdominal or stomach pain
  • bleeding gums
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • blood in the urine or stools
  • bloody nose
  • cough
  • coughing up blood
  • diarrhea
  • difficult or labored breathing
  • difficulty with swallowing
  • dizziness
  • facial swelling
  • feeling of fullness
  • fever or chills
  • headache
  • increased menstrual flow or vaginal bleeding
  • lower back or side pain
  • nausea or vomiting
  • nosebleeds
  • pain in the back, ribs, arms, or legs
  • pain spreading to the left shoulder
  • painful or difficult urination
  • pale skin
  • paralysis
  • pinpoint red or purple spots on the skin
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • skin rash
  • sore throat
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less Common

  • Blurred vision
  • chest pain
  • nervousness
  • pounding in the ears
  • slow or fast heartbeats

Incidence Not Known

  • Blisters on the skin
  • blue lips, fingernails, or skin
  • difficult or fast breathing
  • sores on the skin

Some side effects of filgrastim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

  • Cracked lips
  • difficulty having a bowel movement (stool)
  • swelling or inflammation of the mouth

For Healthcare Professionals

Applies to filgrastim: injectable solution

Cardiovascular

Common (1% to 10%): Hypotension

Uncommon (0.1% to 1%): Veno-occlusive diseased, fluid volume disturbances, capillary leak syndrome[Ref]

Dermatologic

Very common (10% or more): Rash, alopecia

Uncommon (0.1% to 1%): Sweets syndrome, cutaneous vasculitis[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea, vomiting, constipation, nausea, mucosal inflammation[Ref]

Genitourinary

Common (1% to 10%): Dysuria

Uncommon (0.1% to 1%): Urine abnormality, proteinuria, hematuria[Ref]

Hematologic

Very common (10% or more): Thrombocytopenia, leukocytosis, anemia, splenomegaly

Common (1% to 10%): Splenic rupture

Uncommon (0.1% to 1%): Sickle cell crisis[Ref]

Hepatic

Very common (10% or more): Gamma-glutamyltransferase increased, blood alkaline phosphatase increased, hepatomegaly

Uncommon (0.1% to 1%): Aspartate aminotransferase increased[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity

Uncommon (0.1% to 1%): Graft versus host disease, anaphylactic reaction[Ref]

Local

Common (1% to 10%): Injection site reaction[Ref]

Metabolic

Very common (10% or more): Blood uric acid increased, blood lactate dehydrogenase increased, decreased appetite, hyperuricemia, blood glucose decreased

Uncommon (0.1% to 1%): Pseudogout[Ref]

Musculoskeletal

Very common (10% or more): Bone pain, back pain, arthralgia, myalgia, pain in extremity, musculoskeletal pain, musculoskeletal chest pain, neck pain

Common (1% to 10%): Osteoporosis

Uncommon (0.1% to 1%): Exacerbation of rheumatoid arthritis[Ref]

Nervous system

Very common (10% or more): Headache[Ref]

Other

Very common (10% or more): Asthenia, fatigue, pain[Ref]

Renal

Common (1% to 10%): Glomerulonephritis[Ref]

Respiratory

Very common (10% or more): Oropharyngeal pain, cough, dyspnea, epistaxis

Common (1% to 10%): Hemoptysis

Uncommon (0.1% to 1%): Acute respiratory distress syndrome, respiratory failure, pulmonary edema, interstitial lung disease, lung infiltration, pulmonary hemorrhage[Ref]

References

1. "Product Information. Neupogen (filgrastim)." Amgen, Thousand Oaks, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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