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Fenoldopam Side Effects

Medically reviewed by Last updated on Oct 3, 2022.

Applies to fenoldopam: intravenous solution.

Serious side effects of Fenoldopam

Along with its needed effects, fenoldopam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fenoldopam:

Less common or rare

  • Chest pain or discomfort
  • convulsions
  • decrease in the amount of urine
  • dilated neck veins
  • dry mouth
  • extreme fatigue
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • increased thirst
  • irregular breathing
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • swelling of the face, fingers, feet, or lower legs
  • unusual tiredness or weakness
  • weight gain

Incidence not known

  • Blurred vision
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating

Other side effects of Fenoldopam

Some side effects of fenoldopam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • headache

Less common or rare

  • Abdominal or stomach pain
  • anxiety
  • dizziness
  • increased sweating
  • muscle spasms
  • trouble sleeping

For Healthcare Professionals

Applies to fenoldopam: intravenous solution.


The most common adverse reactions were headache, cutaneous dilation (flushing), nausea, and hypotension.[Ref]

Nervous system

Very common (10% or more): Headache (24%)

Frequency not reported: Dizziness[Ref]


Very common (10% or more): Nausea (12%)

Common (1% to 10%): Vomiting

Frequency not reported: Abdominal pain, abdominal distention[Ref]


Common (1% to 10%): Injection site reaction[Ref]


Common (1% to 10%): ECG T wave inversion

Frequency not reported: Extrasystoles, palpitations, cardiac failure, ischemic heart disease, myocardial infarction, angina pectoris, tachycardia

Postmarketing reports: Cardiogenic shock, hypotension, ECG ST segment depression[Ref]


Frequency not reported: Chest pain, pyrexia, blood lactate dehydrogenase increased[Ref]


Frequency not reported: Hypokalemia, blood glucose increased

Postmarketing reports: Oxygen saturation decreased[Ref]


Frequency not reported: Nervousness/anxiety, insomnia[Ref]


Frequency not reported: Blood urea increased, blood creatinine increased[Ref]


Frequency not reported: Hyperhidrosis[Ref]


Frequency not reported: Oliguria[Ref]


Frequency not reported: Transaminases increased[Ref]


Frequency not reported: Muscle spasms[Ref]


Frequency not reported: Intraocular pressure increased[Ref]


1. "Product Information. Corlopam (fenoldopam)." Neurex (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.