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Fenoldopam Side Effects

For the Consumer

Applies to fenoldopam: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by fenoldopam. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking fenoldopam, check with your doctor or nurse immediately:

Less common or rare:
  • Chest pain or discomfort
  • convulsions
  • decrease in the amount of urine
  • dilated neck veins
  • dry mouth
  • extreme fatigue
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • increased thirst
  • irregular breathing
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • swelling of the face, fingers, feet, or lower legs
  • unusual tiredness or weakness
  • weight gain
Incidence not known:
  • Blurred vision
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating

Minor Side Effects

Some of the side effects that can occur with fenoldopam may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • headache
Less common or rare:
  • Abdominal or stomach pain
  • anxiety
  • dizziness
  • increased sweating
  • muscle spasms
  • trouble sleeping

For Healthcare Professionals

Applies to fenoldopam: intravenous solution


The most common adverse reactions were headache, cutaneous dilation (flushing), nausea, and hypotension.[Ref]

Nervous system

Very common (10% or more): Headache (24%)
Frequency not reported: Dizziness[Ref]


Very common (10% or more): Nausea (12%)
Common (1% to 10%): Vomiting
Frequency not reported: Abdominal pain, abdominal distention[Ref]


Common (1% to 10%): Injection site reaction[Ref]


Common (1% to 10%): ECG T wave inversion
Frequency not reported: Extrasystoles, palpitations, cardiac failure, ischemic heart disease, myocardial infarction, angina pectoris, tachycardia
Postmarketing reports: Cardiogenic shock, hypotension, ECG ST segment depression[Ref]


Frequency not reported: Chest pain, pyrexia, blood lactate dehydrogenase increased[Ref]


Frequency not reported: Hypokalemia, blood glucose increased
Postmarketing reports: Oxygen saturation decreased[Ref]


Frequency not reported: Nervousness/anxiety, insomnia[Ref]


Frequency not reported: Blood urea increased, blood creatinine increased[Ref]


Frequency not reported: Hyperhidrosis[Ref]


Frequency not reported: Oliguria[Ref]


Frequency not reported: Transaminases increased[Ref]


Frequency not reported: Muscle spasms[Ref]


Frequency not reported: Intraocular pressure increased[Ref]


1. "Product Information. Corlopam (fenoldopam)." Neurex, Menlo Park, CA.

Not all side effects for fenoldopam may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.