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Ethacrynic acid Side Effects

For the Consumer

Applies to ethacrynic acid: oral tablet

In addition to its needed effects, some unwanted effects may be caused by ethacrynic acid. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking ethacrynic acid:

Rare
  • Bleeding gums
  • bloating
  • clay-colored stools
  • constipation
  • darkened urine
  • indigestion
  • itching
  • large, flat, blue or purplish patches in the skin
  • loss of appetite
  • nausea
  • painful knees and ankles
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • pinpoint red spots on skin
  • raised red swellings on the skin, the buttocks, legs, or ankles
  • skin rash
  • unpleasant breath odor
  • vomiting of blood
  • yellow eyes or skin
Incidence not determined
  • Anxiety
  • black, tarry stools
  • blood in urine
  • blurred vision
  • cold sweats
  • coma
  • confusion
  • convulsions (seizures)
  • cool, pale skin
  • cough or hoarseness
  • depression
  • dizziness
  • dry mouth
  • fast heartbeat
  • fever with or without chills
  • flushed, dry skin
  • fruit-like breath odor
  • general feeling of tiredness or weakness
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • joint pain, stiffness, or swelling
  • lower back, side, or stomach pain
  • nausea
  • nervousness
  • nightmares
  • painful or difficult urination
  • pale skin
  • shakiness
  • shortness of breath
  • slurred speech
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sweating
  • swelling of the feet or lower legs
  • troubled breathing
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • watery and severe diarrhea

If any of the following symptoms of overdose occur while taking ethacrynic acid, get emergency help immediately:

Symptoms of overdose:
  • Confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • increase in heart rate
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • rapid breathing
  • sunken eyes
  • thirst
  • trembling
  • weakness and heaviness of the legs
  • wrinkled skin

Minor Side Effects

Some of the side effects that can occur with ethacrynic acid may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not determined
  • Continuing ringing or buzzing or other unexplained noise in ears
  • difficulty swallowing
  • fear
  • feeling of constant movement of self or surroundings
  • feeling of fullness in the ears
  • general feeling of discomfort or illness
  • hearing loss
  • mild diarrhea
  • sensation of spinning
  • stomach soreness or discomfort
  • weight loss

For Healthcare Professionals

Applies to ethacrynic acid: intravenous powder for injection, oral tablet

Metabolic

Frequency not reported: Anorexia, reversible hyperuricemia, hyperglycemia, acute gout, acute symptomatic hypoglycemia with convulsions, blood glucose increased, glucose tolerance test altered[Ref]

Gastrointestinal

Frequency not reported: Abdominal discomfort or pain, dysphagia, nausea, vomiting, diarrhea, watery profuse diarrhea, gastrointestinal bleeding, acute pancreatitis[Ref]

Nervous system

Frequency not reported: Deafness, tinnitus, vertigo with fullness in the ears, headache[Ref]

Other

Frequency not reported: Malaise, fatigue, fever, chills[Ref]

Hematologic

Frequency not reported: Agranulocytosis, severe neutropenia, thrombocytopenia[Ref]

Dermatologic

Frequency not reported: Henoch Schonlein purpura, rash[Ref]

Genitourinary

Frequency not reported: Urinary urate excretion decreased, hematuria[Ref]

Hepatic

Frequency not reported: Jaundice, abnormal liver function tests[Ref]

Psychiatric

Frequency not reported: Apprehension, confusion[Ref]

Local

Frequency not reported: Local irritation, local pain[Ref]

Ocular

Frequency not reported: Blurred vision[Ref]

References

1. "Product Information. Edecrin (ethacrynic acid)." Merck & Co, Inc, West Point, PA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for ethacrynic acid may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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