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Entrectinib Side Effects

Medically reviewed by Last updated on May 26, 2023.

Applies to entrectinib: oral capsule, oral pellet.

Serious side effects of Entrectinib

Along with its needed effects, entrectinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking entrectinib:

More common

Less common

Other side effects of Entrectinib

Some side effects of entrectinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to entrectinib: oral capsule, oral pellet.


Very common (10% or more): Anemia (67%), lymphopenia (40%), neutropenia (28%)[Ref]


Common (1% to 10%): Pneumonia, sepsis[Ref]


Very common (10% or more): Myalgia (e.g., musculoskeletal pain, musculoskeletal chest pain, myalgia, neck pain) (28%), fractures in children (e.g., hip, femoral or tibial shaft, bilateral femoral neck) (23%), arthralgia (21%), muscular weakness (12%), back pain (12%), pain in extremity (11%)

Common (1% to 10%): Fractures in adults (e.g. hip, femoral or tibial shaft, bilateral femoral neck)

Very rare (less than 0.01%): Tumor lysis syndrome (TLS)[Ref]


Very common (10% or more): Vision disorders (e.g., blindness, cataract, cortical cataract, corneal erosion, diplopia, eye disorder, photophobia, photopsia, retinal hemorrhage, vision blurred, visual impairment, vitreous adhesions, vitreous detachment, vitreous floaters) (21%)[Ref]


Very common (10% or more): Hyperuricemia (52%), hypernatremia (35%), hypocalcemia (34%), hypophosphatemia (30%), hypoalbuminemia (28%), weight gain (25%), hyperkalemia (25%), anorexia (13%), dehydration (10%)

Uncommon (0.1% to 1%): Tumor lysis syndrome (TLS)[Ref]


Very common (10% or more): Cognitive impairment (e.g., amnesia, aphasia, cognitive disorder, confusional state, delirium, disturbance in attention, hallucinations, visual hallucination, memory impairment, mental disorder, mental status changes (27%), sleep disorder (e.g., hypersomnia, insomnia, sleep disorder, somnolence) (14%), mood disorder (e.g., anxiety, affect lability, affective disorder, agitation, depressed mood, euphoric mood, mood altered, mood swings, irritability, depression, persistent depressive disorder, psychomotor retardation) (10%)[Ref]


Very common (10% or more): Urinary tract infection (13%)[Ref]


Very common (10% or more): Increased AST (44%), increased ALT (38%), increased alkaline phosphatase (25%)[Ref]


Very common (10% or more): Dyspnea (30%), cough (24%), lung infection (e.g., lower respiratory tract infection, lung infection, pneumonia, respiratory tract infection) (10%)

Common (1% to 10%): Pleural effusion, pulmonary embolism, respiratory failure, hypoxia[Ref]


Very common (10% or more): Fatigue/asthenia (48%), edema (e.g., face edema, fluid retention, generalized edema, localized edema, edema, edema peripheral, peripheral swelling) (40%), pyrexia (21%)[Ref]


The most common adverse reactions (20% or greater) are fatigue, constipation, dysgeusia, edema, dizziness, diarrhea, nausea, dysesthesia, dyspnea, myalgia, cognitive impairment, increased weight, cough, vomiting, pyrexia, arthralgia, and vision disorders.[Ref]

Nervous system

Very common (10% or more): Dysgeusia (44%), dizziness (e.g., dizziness, vertigo, dizziness postural) (38%), dysesthesia (e.g., paresthesia, hyperesthesia, hypoesthesia, dysesthesia, oral hypoesthesia, palmar-plantar erythrodysesthesia, oral paresthesia, genital hypoesthesia) (34%), headache (21%), paresthesia (20%), peripheral sensory neuropathy (e.g., neuralgia, neuropathy peripheral, peripheral motor neuropathy, peripheral sensory neuropathy) (18%), ataxia (e.g., ataxia, balance disorder, gait disturbance) (18%), dysphagia (10%)

Common (1% to 10%): Aphasia, fall[Ref]


Very common (10% or more): Increased creatinine (73%)[Ref]


Very common (10% or more): Hypotension (e.g., hypotension, orthostatic hypotension) (18%)

Common (1% to 10%): Congestive heart failure (CHF), QT interval prolongation, syncope[Ref]


Very common (10% or more): Rash (e.g., rash, rash maculopapular, rash pruritic, rash erythematous, rash papular) (11%)[Ref]


Very common (10% or more): Constipation (46%), diarrhea (35%), nausea (34%), increased lipase (28%), increased amylase (26%), vomiting (24%), abdominal pain (e.g., abdominal pain upper, abdominal pain, lower abdominal discomfort, abdominal tenderness) (16%)

Uncommon (0.1% to 1%): Large intestine perforation[Ref]


1. (2019) "Product Information. Rozlytrek (entrectinib)." Genentech

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.