Generic Name: entrectinib (en-TREK-ti-nib)
Medically reviewed by Drugs.com. Last updated on May 25, 2020.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Antineoplastic Agent
Pharmacologic Class: Tyrosine Kinase Inhibitor
Uses for entrectinib
Entrectinib is used to treat metastatic (lung cancer that has already spread) non-small cell lung cancer (NSCLC) that is caused by a gene called ROS1. Entrectinib is also used to treat solid tumors (cancer) that are caused by certain abnormal NTRK genes and have spread or if surgery to remove the cancer is likely to cause severe complications, and there is no acceptable treatment option or the cancer grew or spread on other treatments. Your doctor will perform a test before you take entrectinib.
Entrectinib belongs to the group of medicines called antineoplastics (cancer medicines). It works by interfering with the growth of cancer cells, which are eventually destroyed.
Entrectinib is available only with your doctor's prescription.
Before using entrectinib
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For entrectinib, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to entrectinib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of entrectinib to treat ROS1-positive NSCLC in children. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of entrectinib to treat NTRK gene fusion-positive solid tumors in children 12 years of age and older. However, safety and efficacy have not been established in children younger than 12 years of age.
Appropriate studies on the relationship of age to the effects of entrectinib have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking entrectinib, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using entrectinib with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using entrectinib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Inotuzumab Ozogamicin
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- St John's Wort
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using entrectinib with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use entrectinib, or give you special instructions about the use of food, alcohol, or tobacco.
- Grapefruit Juice
Other medical problems
The presence of other medical problems may affect the use of entrectinib. Make sure you tell your doctor if you have any other medical problems, especially:
- Bone problems or
- Congestive heart failure or
- Electrolyte imbalance or
- Eye or vision problems or
- Heart disease (eg, myocarditis) or
- Heart rhythm problems (eg, QT prolongation, slow heartbeat) or
- Hyperuricemia (high uric acid in the blood) or
- Liver problems—Use with caution. May make these conditions worse.
Proper use of entrectinib
Medicines used to treat cancer are very strong and can have many side effects. Before using entrectinib, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Take entrectinib only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
Entrectinib usually comes with patient information leaflet. Read and follow the instructions carefully and make sure you understand them before taking entrectinib. Ask your doctor if you have any questions.
Swallow the capsule whole. Do not open, crush, chew, or dissolve it. You may take entrectinib with or without food.
Do not eat grapefruit or drink grapefruit juice while you are using entrectinib. Grapefruit and grapefruit juice may change the amount of medicine that is absorbed in the body.
The dose of entrectinib will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of entrectinib. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (capsules):
- For ROS1-positive non-small cell lung cancer:
- Adults—600 milligrams (mg) once a day.
- Children—Use and dose must be determined by your doctor.
- For NTRK gene fusion-positive solid tumors:
- Adults—600 milligrams (mg) once a day.
- Children 12 years of age and older—Dose is based on body surface area (BSA) and must be determined by your doctor:
- BSA greater than 1.50 meter squared (m2)—600 mg once a day.
- BSA 1.11 to 1.50 m2—500 mg once a day.
- BSA 0.91 to 1.10 m2—400 mg once a day.
- Children younger than 12 years of age—Use and dose must be determined by your doctor.
- For ROS1-positive non-small cell lung cancer:
If you miss a dose of entrectinib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
If your next dose is within 12 hours, skip the missed dose and return to your regular dosing schedule.
If you vomit after taking a dose, take another dose as soon as possible.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions while using entrectinib
It is very important that your doctor check your or your child's progress at regular visits to make sure entrectinib is working properly. Blood tests may be needed to check for unwanted effects.
Using entrectinib while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using entrectinib to make sure you are not pregnant. Use an effective form of birth control during treatment and for at least 5 weeks after your final dose. Males with female partners who are able to become pregnant should use an effective form of birth control during treatment and for 3 months after the last dose. If you think you have become pregnant, tell your doctor right away.
Check with your doctor right away if you or your child have a chest pain that is worse than usual, trouble breathing, nausea or vomiting, pain or discomfort in your arms, jaw, back, or neck, feel faint, or you are sweating. Entrectinib may worsen the symptoms of an existing heart problem.
Entrectinib may cause dizziness, fainting, tiredness, blurred vision, memory loss, changes in mental status, confusion, or hallucinations. Make sure you know how you react to entrectinib before you drive, use machines, or do other jobs that require you to be alert.
Entrectinib may increase your risk of bone fractures. Ask your doctor about ways to keep your bones strong to help prevent fractures.
Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.
Contact your doctor right away if you or your child have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you or your child to have your eyes checked by an ophthalmologist (eye doctor).
Cancer medicines can cause constipation, diarrhea, nausea, or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Entrectinib side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- Abdominal or stomach pain or tenderness
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- change in color vision
- clay colored stools
- dark urine
- decreased appetite
- defects in intelligence, short-term memory, learning ability, and attention
- difficulty seeing at night
- increased sensitivity of the eyes to sunlight
- itching or skin rash
- joint pain, stiffness, or swelling
- loss of appetite
- lower back, side, or stomach pain
- nausea and vomiting
- problems with balance
- sleepiness or unusual drowsiness
- swelling of the feet or lower legs
- trouble sleeping
- unusual tiredness or weakness
- yellow eyes or skin
- Chest pain
- decreased urine output
- dilated neck veins
- double vision
- extreme fatigue
- irregular breathing
- irregular heartbeat recurrent
- loss of memory
- problems with memory
- problems with speech or speaking
- seeing double
- seeing, hearing, or feeling things that are not there
- swelling of the face, fingers, feet, or lower legs
- tightness in the chest
- trouble remembering
- troubled breathing
- weight gain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Change or loss of taste
- difficulty having a bowel movement (stool)
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
More about entrectinib
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: multikinase inhibitors
- Other brands
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.