Elahere Side Effects
Generic name: mirvetuximab soravtansine
Medically reviewed by Drugs.com. Last updated on Jul 4, 2024.
Note: This document provides detailed information about Elahere Side Effects associated with mirvetuximab soravtansine. Some dosage forms listed on this page may not apply specifically to the brand name Elahere.
Applies to mirvetuximab soravtansine: intravenous solution.
Important warnings
This medicine can cause some serious health issues
Intravenous route (solution)
Warning: Ocular Toxicity. Mirvetuximab soravtansine-gynx can cause severe ocular toxicities, including visual impairment, keratopathy, dry eye, photophobia, eye pain, and uveitis.Conduct an ophthalmic exam including visual acuity and slit lamp exam prior to initiation of mirvetuximab soravtansine-gynx, every other cycle for the first 8 cycles, and as clinically indicated.Administer prophylactic artificial tears and ophthalmic topical steroids.Withhold mirvetuximab soravtansine-gynx for ocular toxicities until improvement and resume at the same or reduced dose.Discontinue mirvetuximab soravtansine-gynx for Grade 4 ocular toxicities.
Precautions
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Receiving this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting treatment. Use an effective form of birth control to prevent pregnancy while you are receiving this medicine and for at least 7 months after the last dose. If you think you have become pregnant while receiving this medicine, tell your doctor right away.
This medicine may cause eye or vision problems (eg, visual impairment, keratopathy, dry eye, photophobia, eye pain, and uveitis). Check with your doctor right away if you have blurred vision, change in vision, difficulty seeing at night, eye pain, increased sensitivity of the eyes to sunlight, redness of the eye, or tearing. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
This medicine may cause pneumonitis (swelling of the lungs). Check with your doctor right away if you have chest pain, chills, cough, fever, general feeling of discomfort or illness, thickening of bronchial secretions, or trouble breathing
Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations, weakness in the arms, hands, legs, or feet, or unsteadiness. These could be symptoms of a condition called peripheral neuropathy.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of Elahere
Along with its needed effects, mirvetuximab soravtansine (the active ingredient contained in Elahere) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking mirvetuximab soravtansine:
More common side effects
- black, tarry stools
- blindness
- blurred vision
- burning, numbness, tingling, or painful sensations
- change in vision
- chills
- cough
- decreased vision
- difficulty seeing at night
- double vision
- dry eye
- eye redness, irritation, or pain
- fever
- increased sensitivity of the eyes to sunlight
- lower back or side pain
- nausea
- painful, irritation of the clear front part of the eye
- painful or difficult urination
- pale skin
- seeing double
- severe constipation
- sore throat
- stomach pain
- trouble breathing
- ulcers, sores, or white spots in the mouth
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting
- watering of the eyes
- weakness in the arms, hands, legs, or feet
Less common side effects
- bleeding gums
- blood in the urine or stools
- chest pain
- cough or hoarseness
- general feeling of discomfort or illness
- pinpoint red spots on the skin
- stomach bloating
- thickening of bronchial secretions
Other side effects of Elahere
Some side effects of mirvetuximab soravtansine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- decreased appetite
- diarrhea
- muscle or joint pain
For healthcare professionals
Applies to mirvetuximab soravtansine: intravenous solution.
General adverse events
The most common adverse reactions with a frequency of 20% or more, including laboratory abnormalities, were vision impairment, fatigue, increased aspartate aminotransferase, nausea, increased alanine aminotransferase, keratopathy, abdominal pain, decreased lymphocytes, peripheral neuropathy, diarrhea, decreased albumin, constipation, increased alkaline phosphatase, dry eye, decreased magnesium, decreased leukocytes, decreased neutrophils, and decreased hemoglobin.
The most common side effects resulting in discontinuation were intestinal obstruction (2%) and thrombocytopenia (2%).
Serious adverse reactions were reported in 31% of patients, of which the most common were intestinal obstruction, ascites, infection, and pleural effusion.[Ref]
Gastrointestinal
- Very common (10% or more): Abdominal distension (11%), abdominal pain (36%), constipation (30%), diarrhea (31%), nausea (40%), vomiting (19%)[Ref]
Hematologic
- Common (1% to 10%): Thrombocytopenia[Ref]
Hypersensitivity
- Common (1% to 10%): Infusion related reactions/hypersensitivity[Ref]
Musculoskeletal
Nervous system
- Very common (10% or more): Peripheral neuropathy (33%)[Ref]
Ocular
- Very common (10% or more): Cataract (18%), dry eye (27%), eye pain (10%), keratopathy (37%), photophobia (17%), vision impairment (50%)
- Common (1% to 10%): Uveitis[Ref]
Other
- Very common (10% or more): Fatigue (49%)[Ref]
Respiratory
Metabolic
- Very common (10% or more): Decreased appetite (18%)[Ref]
See also:
Keytruda
Keytruda is used to treat multiple types of cancer such as melanoma, non-small cell lung cancer ...
Pembrolizumab
Pembrolizumab (Keytruda) is a monoclonal antibody cancer medicine used to treat
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Avastin
Avastin is used to brain tumors and cancers of the kidney, colon, rectum, or lung. Learn about side ...
Taxol
Taxol (paclitaxel) is used to treat breast cancer, lung cancer, and ovarian cancer. Includes Taxol ...
Lynparza
Lynparza (olaparib) is used to treat ovarian cancer, breast cancer, pancreatic cancer, and prostate ...
Zirabev
Zirabev is used for cervical cancer, colorectal cancer, fallopian tube cancer, glioblastoma ...
Mvasi
Mvasi is used for cervical cancer, colorectal cancer, fallopian tube cancer, glioblastoma ...
Zejula
Zejula (niraparib) is used to treat recurrent ovarian, fallopian tube, or peritoneal cancer ...
References
1. (2022) "Product Information. Elahere (mirvetuximab soravtansine)." ImmunoGen, Inc., 1
Frequently asked questions
More about Elahere (mirvetuximab soravtansine)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (10)
- Drug images
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: miscellaneous antineoplastics
- Breastfeeding
- En español
Patient resources
Professional resources
Related treatment guides
Further information
Elahere side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.