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Mirvetuximab Soravtansine use while Breastfeeding

Medically reviewed by Drugs.com. Last updated on May 15, 2023.

Drugs containing Mirvetuximab Soravtansine: Elahere

Mirvetuximab Soravtansine Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the clinical use of mirvetuximab soravtansine during breastfeeding. Because mirvetuximab is a large protein molecule with a molecular weight of 150,000 Da, the amount in milk is likely to be very low.[1] It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] However, mirvetuximab is conjugated with the small-molecule toxin, mafodotin, which might be excreted into milk. The manufacturer recommends that breastfeeding be discontinued during therapy and for 1 month after the last dose.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.
Stratigakis A, Paty D, Zou P, et al. A regression approach for assessing large molecular drug concentration in breast milk. Reprod Breed 2023;3:199-207. doi:10.1016/j.repbre.2023.10.003 [CrossRef]
2.
Anderson PO. Monoclonal antibodies during breastfeeding. Breastfeed Med 2021;16:591-3. [PubMed: 33956488]

Substance Identification

Substance Name

Mirvetuximab Soravtansine

CAS Registry Number

1453084-37-1

Drug Class

Breast Feeding

Lactation

Milk, Human

Immunoconjugates

Antibodies, Monoclonal, Humanized

Antineoplastic Agents

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Further information

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