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Dyna-Hex Side Effects

Generic Name: chlorhexidine topical

Note: This page contains information about the side effects of chlorhexidine topical. Some of the dosage forms included on this document may not apply to the brand name Dyna-Hex.

For the Consumer

Applies to chlorhexidine topical: topical application cream, topical application dressing, topical application gel/jelly, topical application liquid, topical application lotion, topical application pad, topical application solution, topical application sponge

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by chlorhexidine topical (the active ingredient contained in Dyna-Hex). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking chlorhexidine topical:

Incidence not known:
  • Blistering, burning, itching, peeling, skin rash, redness, swelling, or other signs of irritation on the skin
  • swelling of the face, hands, or feet
  • trouble breathing

For Healthcare Professionals

Applies to chlorhexidine topical: compounding liquid, mucous membrane insert, mucous membrane liquid, topical dressing, topical liquid, topical pad, topical soap, topical solution, topical sponge

General

The most commonly reported side effects include toothache, tongue coating, skin irritation and hypersensitivity reactions.[Ref]

Gastrointestinal

Very common (10% or more): Toothache (up to 50.7%)
Common (1% to 10%): Dry mouth, glossodynia, oral paresthesia, dyspepsia, ulcerative stomatitis, gum hyperplasia
Frequency not reported: Mouth irritation, coated tongue, desquamation/superficial desquamation/oral mucosa swelling, parotid gland swelling, burning sensation of the tongue, increased dental calculus formation, aphthous ulcer, gingivitis/grossly obvious gingivitis, geographic tongue, tooth disorder, dental/gingival/mouth pain, broken/cracked/fractured teeth, mobile teeth, lost bridges/crowns/fillings, discoloration of the teeth, gums, and dorsum of the tongue
Postmarketing reports: Stomatitis, glossitis, ulcer, glossal edema, sialadenitis/inflammation of the salivary glands[Ref]

Toothache occurred most often in patients receiving the periodontal chip, and included dental/gingival/mouth pain, tenderness, aching, throbbing, soreness, discomfort, or sensitivity.

Tooth disorder occurred most often in patients receiving the periodontal chip, and included broken/cracked/fractured teeth, mobile teeth, and lost bridges/crowns/fillings.[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infection (up to 28.4%), sinusitis (up to 13.8%)
Common (1% to 10%): Bronchitis, pharyngitis
Frequency not reported: Bronchospasm, rhinitis, coughing, dyspnea[Ref]

Bronchospasm occurred with hypersensitivity reactions.

Upper respiratory tract infection and sinusitis have occurred most commonly in patients receiving the periodontal chip.[Ref]

Nervous system

Common (1% to 10%): Ageusia/dysgeusia, hypoesthesia
Frequency not reported: Transient dysgeusia, headache, loss of consciousness
Postmarketing reports: Hypesthesia, paresthesia[Ref]

Musculoskeletal

Common (1% to 10%): Arthrosis, tendinitis
Frequency not reported: Back pain, myalgia, arthralgia[Ref]

Local

Frequency not reported: Ulceration, desquamation, keratinization, mucocele, short frenum, pain, tenderness, aching, throbbing, soreness, discomfort, sensitivity
Postmarketing reports: Minor irritation[Ref]

Dermatologic

Frequency not reported: Rash, erythema/generalized erythema, urticaria, dermatitis, pruritus, eczema, skin irritation, blisters, cold sweat, irritative or allergic skin reactions[Ref]

Rash, erythema, and urticaria occurred with hypersensitivity reactions.

Dermatitis, pruritus, erythema, eczema, rash, urticaria, skin irritation, and blisters occurred with allergic skin reactions.[Ref]

Other

Frequency not reported: Chemical burns in neonates, trauma, abscess, influenza-like symptoms, deafness, sensitive tissue irritation[Ref]

Cardiovascular

Frequency not reported: Cardiac arrest, circulatory collapse, hypotension, tachycardia, hypertension[Ref]

Cardiac arrest, circulatory collapse, hypotension, and tachycardia occurred as hypersensitivity reactions.[Ref]

Hypersensitivity

Frequency not reported: Anaphylactic shock, anaphylactoid reactions/fatal anaphylactic reactions
Postmarketing reports: Hypersensitivity and anaphylaxis[Ref]

Ocular

Frequency not reported: Irreversible corneal damage, irritation to the conjunctiva[Ref]

Exposure of the eye to chlorhexidine cleanser, generally during preparation for facial surgery, has resulted in eye pain, edema of the epithelium, keratitis, inflammation of the conjunctiva, corneal epithelial cell loss, chronic corneal ulcers, and opacification. Corneal transplantation to correct permanent damage has been required in some patients.

Allergic conjunctivitis is rarely associated with the use of contact lens solutions which contain low concentrations of chlorhexidine as a preservative.[Ref]

Genitourinary

Hematuria occurred after bladder irrigation.[Ref]

Frequency not reported: Dysmenorrhea, hematuria[Ref]

Immunologic

Frequency not reported: Allergy[Ref]

References

1. "Product Information. Chlorhexidine Gluconate (chlorhexidine topical)." A-S Medication Solutions, Chicago, IL.

2. "Product Information. Peridex (chlorhexidine)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.

3. "Product Information. Biopatch (chlorhexidine topical)." Johnson and Johnson Medical Inc, Arlington, TX.

4. Cerner Multum, Inc. "Australian Product Information." O 0

5. "Product Information. Periochip (chlorhexidine topical)." Astra USA, Westborough, MA.

6. "Product Information. Hibiclens (chlorhexidine topical)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.

7. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Dyna-Hex may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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