Duac Side Effects
Generic name: benzoyl peroxide / clindamycin topical
Medically reviewed by Drugs.com. Last updated on Jun 15, 2024.
Note: This document provides detailed information about Duac Side Effects associated with benzoyl peroxide / clindamycin topical. Some dosage forms listed on this page may not apply specifically to the brand name Duac.
Applies to benzoyl peroxide/clindamycin topical: topical gel, topical kit.
Important warnings
This medicine can cause some serious health issues
This medicine can cause a rare but serious allergic reaction or severe skin irritation. Stop using this medicine and get emergency medical help if you have: hives, itching; difficult breathing, feeling light-headed; or swelling of your face, lips, tongue, or throat.
Benzoyl peroxide can cause a rare but serious allergic reaction or severe skin irritation. These reactions may occur just a few minutes after you apply the medicine, or within a day or longer afterward.
Stop using this medicine and get emergency medical help if you have signs of an allergic reaction: hives, itching; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
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severe redness, burning, stinging, or peeling of treated skin areas; or
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diarrhea that is watery or bloody.
Common side effects may include:
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mild burning or stinging;
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itching or tingly feeling;
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dryness or peeling of treated skin; or
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redness or other irritation.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For healthcare professionals
Applies to benzoyl peroxide/clindamycin topical: topical gel, topical kit.
General adverse events
The most frequently reported side effects were erythema, scaling, peeling, dry skin, and itching.[Ref]
Dermatologic
- Very common (10% or more): Erythema (up to 28%), scaling (up to 19%), peeling (up to 17%), dry skin (up to 15%), itching (up to 15%)
- Common (1% to 10%): Pruritus, sunburn, burning, stinging
- Uncommon (0.1% to 1%): Contact dermatitis, rash, acne worsened
- Postmarketing reports: Urticaria[Ref]
Gastrointestinal
- Frequency not reported: Colitis
- Postmarketing reports: Pseudomembranous colitis, hemorrhagic diarrhea, diarrhea, abdominal pain[Ref]
Immunologic
- Postmarketing reports: Anaphylaxis, allergic reaction[Ref]
Local
- Common (1% to 10%): Application site reaction
- Uncommon (0.1% to 1%): Application site pain, application site exfoliation, application site irritation
- Postmarketing reports: Discoloration[Ref]
Nervous system
References
1. (2022) "Product Information. BenzaClin (benzoyl peroxide-clindamycin topical)." Apothecon Inc
2. (2018) "Product Information. Acanya (benzoyl peroxide-clindamycin topical)." Valeant Pharmaceuticals
3. (2018) "Product Information. Duac (benzoyl peroxide-clindamycin topical)." Stiefel Laboratories Inc
4. (2018) "Product Information. Onexton (benzoyl peroxide-clindamycin topical)." Valeant Pharmaceuticals
More about Duac (benzoyl peroxide / clindamycin topical)
- Check interactions
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- Dosage information
- During pregnancy
- Generic availability
- Drug class: topical acne agents
Patient resources
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Further information
Duac side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.