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Driminate Side Effects

Generic Name: dimenhydrinate

Note: This page contains information about the side effects of dimenhydrinate. Some of the dosage forms included on this document may not apply to the brand name Driminate.

For the Consumer

Applies to dimenhydrinate: oral solution, oral tablets, parenteral injection

Side effects include:

Drowsiness, headache, blurred vision, tinnitus, dryness of the mouth and respiratory passages, incoordination, palpitation, dizziness, hypotension.

Paradoxical CNS stimulation in pediatric patients and occasionally in adults.

With IM injection: Pain at the injection site.

Because dimenhydrinate (the active ingredient contained in Driminate) contains diphenhydramine, the possibility of other diphenhydramine-related adverse effects should also be considered.

For Healthcare Professionals

Applies to dimenhydrinate: compounding powder, injectable solution, oral liquid, oral tablet, oral tablet chewable


The most frequently reported adverse reaction is drowsiness.[Ref]


Frequency not reported: Tachycardia[Ref]


Frequency not reported: Skin rash[Ref]


Frequency not reported: Dry mouth, epigastric distress, nausea[Ref]


Frequency not reported: Difficult or painful urination[Ref]


Frequency not reported: Anorexia[Ref]

Nervous system

Frequency not reported: Drowsiness, dizziness, headache, excitation[Ref]


Frequency not reported: Blurred vision[Ref]


Frequency not reported: Lassitude[Ref]


Frequency not reported: Nervousness, restlessness, insomnia[Ref]


Frequency not reported: Dry nose, dry throat, thickening of bronchial secretions[Ref]


1. "Product Information. Dramamine (dimenhydrinate)" Pharmacia and Upjohn, Kalamazoo, MI.

Not all side effects for Driminate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.