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Diquinol Side Effects

Generic Name: iodoquinol

Note: This document contains side effect information about iodoquinol. Some of the dosage forms listed on this page may not apply to the brand name Diquinol.

For the Consumer

Applies to iodoquinol: oral tablet

Along with its needed effects, iodoquinol (the active ingredient contained in Diquinol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking iodoquinol:

Less Common

With long-term use of high doses

- especially in children
  • Blurred vision or any change in vision
  • clumsiness or unsteadiness
  • decreased vision or eye pain
  • increased weakness
  • muscle pain
  • numbness, tingling, pain, or weakness in hands or feet

Some side effects of iodoquinol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

For Healthcare Professionals

Applies to iodoquinol: compounding powder, oral tablet

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, abdominal cramps, diarrhea, and pruritus ani.[Ref]

Nervous system

Some neuropathy may be irreversible. Seizures and encephalopathy have been reported in at least one patient. Optic atrophy has been reported, generally in children being treated for acrodermatitis enteropathica at daily dosages between 1300 to 3600 mg for up to two years. Visual deterioration is generally irreversible.

Clioquinol, another hydroxyquinoline, was associated with several thousand cases of subacute myelo-optic neuropathy in Japan, leading to its removal from the market. This syndrome consisted of peripheral weakness, spastic paraparesis, dysesthesia, and optic neuropathy.

Because of the neurotoxicity associated with iodoquinol (the active ingredient contained in Diquinol) and its growing use in pediatric patients for the treatment of nonspecific chronic diarrhea in the 1970's, the American Academy of Pediatrics Committee on Drugs issued a statement recommending that products containing clioquinol or iodoquinol not be used in pediatric patients.[Ref]

Nervous system side effects have been reported rarely. These have included peripheral neuropathy and headache. Optic atrophy has been reported, generally in pediatric patients receiving large doses for long periods of time.[Ref]

Dermatologic

Dermatologic side effects have included acneiform papular or pustular skin eruptions, bulla, urticaria, and pruritus. These reactions are related to the iodine content of iodoquinol (the active ingredient contained in Diquinol) [Ref]

Other

Other side effects have included fever, chills, and enlargement of the thyroid.[Ref]

References

1. "Warning on diiodohydroxyquin." Med Lett Drugs Ther 16 (1974): 71-2

2. "Product Information. Yodoxin (iodoquinol)." Glenwood Inc, Tenafly, NJ.

3. Oakley GP Jr "The neurotoxicity of the halogenated hydroxyquinolines. A commentary." JAMA 225 (1973): 395-7

4. American Academy of Pediatrics Committtee on Drugs "Clioquinol (iodochlorhydroxyquin, vioform) and iodoquinol (diiodohydroxyquin): blindness and neuropathy." Pediatrics 86 (1990): 797-8

5. Fisher AK, Walter FG, Szabo S "Iodoquinol associated seizures and radiopacity." J Toxicol Clin Toxicol 31 (1993): 113-20

6. Fleisher DI, Hepler RS, Landau JW "Blindness during diiodohydroxyquin (Diodoquin) therapy: a case report." Pediatrics 54 (1974): 106-8

7. Pittman FE, Westphal MC "Optic atrophy following treatment with diiodohydroxyquin." Pediatrics 54 (1974): 81-3

8. Behrens MM "Letter: Optic atrophy in children after diiodohydroxyquin therapy." JAMA 228 (1974): 693-4

9. Idriss ZH "Letter: Diiodohydroxyquin and optic atrophy." Pediatrics 55 (1975): 299

10. Committee on Drugs "Blindness and neuropathy from diiodohydroxyquin-like drugs." Pediatrics 54 (1974): 378-9

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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