Diquinol Side Effects
Generic name: iodoquinol
Medically reviewed by Drugs.com. Last updated on Sep 26, 2020.
Note: This document contains side effect information about iodoquinol. Some of the dosage forms listed on this page may not apply to the brand name Diquinol.
For the Consumer
Applies to iodoquinol: oral tablets
Side effects include:
Iodism manifested by generalized furunculosis (iodine toxicoderma) and skin reactions (papular and pustular acneiform eruptions, bullae, vegetating or tuberous iododerma), urticaria and pruritus, GI effects (anorexia, nausea, vomiting, diarrhea, abdominal cramps, pruritus ani), fever, chills, headache, vertigo, thyroid enlargement, optic neuritis, optic atrophy, peripheral neuropathy.
For Healthcare Professionals
Applies to iodoquinol: compounding powder, oral tablet
Gastrointestinal side effects have included nausea, vomiting, abdominal cramps, diarrhea, and pruritus ani.[Ref]
Some neuropathy may be irreversible. Seizures and encephalopathy have been reported in at least one patient. Optic atrophy has been reported, generally in children being treated for acrodermatitis enteropathica at daily dosages between 1300 to 3600 mg for up to two years. Visual deterioration is generally irreversible.
Clioquinol, another hydroxyquinoline, was associated with several thousand cases of subacute myelo-optic neuropathy in Japan, leading to its removal from the market. This syndrome consisted of peripheral weakness, spastic paraparesis, dysesthesia, and optic neuropathy.
Because of the neurotoxicity associated with iodoquinol (the active ingredient contained in Diquinol) and its growing use in pediatric patients for the treatment of nonspecific chronic diarrhea in the 1970's, the American Academy of Pediatrics Committee on Drugs issued a statement recommending that products containing clioquinol or iodoquinol not be used in pediatric patients.[Ref]
Nervous system side effects have been reported rarely. These have included peripheral neuropathy and headache. Optic atrophy has been reported, generally in pediatric patients receiving large doses for long periods of time.[Ref]
Dermatologic side effects have included acneiform papular or pustular skin eruptions, bulla, urticaria, and pruritus. These reactions are related to the iodine content of iodoquinol (the active ingredient contained in Diquinol) [Ref]
Other side effects have included fever, chills, and enlargement of the thyroid.[Ref]
1. "Warning on diiodohydroxyquin." Med Lett Drugs Ther 16 (1974): 71-2
2. "Product Information. Yodoxin (iodoquinol)." Glenwood Inc, Tenafly, NJ.
3. Oakley GP Jr "The neurotoxicity of the halogenated hydroxyquinolines. A commentary." JAMA 225 (1973): 395-7
4. Fleisher DI, Hepler RS, Landau JW "Blindness during diiodohydroxyquin (Diodoquin) therapy: a case report." Pediatrics 54 (1974): 106-8
5. Pittman FE, Westphal MC "Optic atrophy following treatment with diiodohydroxyquin." Pediatrics 54 (1974): 81-3
6. Fisher AK, Walter FG, Szabo S "Iodoquinol associated seizures and radiopacity." J Toxicol Clin Toxicol 31 (1993): 113-20
7. American Academy of Pediatrics Committtee on Drugs "Clioquinol (iodochlorhydroxyquin, vioform) and iodoquinol (diiodohydroxyquin): blindness and neuropathy." Pediatrics 86 (1990): 797-8
8. Committee on Drugs "Blindness and neuropathy from diiodohydroxyquin-like drugs." Pediatrics 54 (1974): 378-9
9. Idriss ZH "Letter: Diiodohydroxyquin and optic atrophy." Pediatrics 55 (1975): 299
10. Behrens MM "Letter: Optic atrophy in children after diiodohydroxyquin therapy." JAMA 228 (1974): 693-4
More about Diquinol (iodoquinol)
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Some side effects may not be reported. You may report them to the FDA.