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DicloStream Side Effects

Generic name: diclofenac / menthol topical

Note: This document contains side effect information about diclofenac / menthol topical. Some dosage forms listed on this page may not apply to the brand name DicloStream.

Applies to diclofenac/menthol topical: topical liquid.


Diclofenac and menthol can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Diclofenac and menthol may also cause stomach or intestinal bleeding, which can be fatal.

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop using this medicine and seek emergency medical attention if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Also call your doctor at once if you have:

  • a skin rash, no matter how mild;

  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;

  • liver problems--nausea, diarrhea, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Serious side effects may be more likely in older adults.

Common side effects may include:

  • skin dryness, redness, itching, or rash;

  • blistering or hardening of the treated skin;

  • numbness, tingling, burning pain;

  • acne;

  • flushing (sudden warmth, redness, or tingly feeling);

  • stomach pain, constipation, diarrhea, gas, heartburn, nausea, vomiting; or

  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to diclofenac / menthol topical: topical liquid.


The most common adverse events reported with diclofenac sodium topical solution were application site skin reactions.[Ref]


Very common (10% or more): Dry skin (32%)

Common (1% to 10%): Contact dermatitis (characterized by skin erythema and induration), contact dermatitis with vesicles and pruritus, application site pruritus

Application site reactions were reported as dryness, erythema, induration, vesicles, paresthesia, pruritus, vasodilation, acne, and urticaria.


Common (1% to 10%): Ecchymosis

Postmarketing reports: Rectal hemorrhage


Postmarketing reports: Allergic reaction


Common (1% to 10%): Pharyngitis, sinusitis

Postmarketing reports: Asthma, dyspnea, laryngismus, laryngitis


Common (1% to 10%): Dyspepsia, abdominal pain, flatulence, diarrhea, nausea, constipation, halitosis

Postmarketing reports: Dry mouth, gastroenteritis, decreased appetite, mouth ulceration, ulcerative stomatitis


Postmarketing reports: Back pain, leg cramps, myalgia


Postmarketing reports: Increased creatinine


Common (1% to 10%): Rash (non-application site), dry skin (non-application site)

Postmarketing reports: Face edema, eczema, rash, pruritus, skin discoloration, urticaria


Postmarketing reports: Depression


Postmarketing reports: Asthenia, body odor, pain

Nervous system

Common (1% to 10%): Paresthesia

Postmarketing reports: Headache, neck rigidity, dizziness, drowsiness, lethargy


Common (1% to 10%): Edema

Postmarketing reports: Chest pain, palpitation, cardiovascular disorder

More about DicloStream (diclofenac / menthol topical)

Patient resources

Professional resources

Related treatment guides


1. "Product Information. DicloStream (diclofenac-menthol topical)." UpStream Pharma LLC (2019):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.