DicloStream Side Effects
Generic name: diclofenac / menthol topical
Note: This document provides detailed information about DicloStream Side Effects associated with diclofenac / menthol topical. Some dosage forms listed on this page may not apply specifically to the brand name DicloStream.
Applies to diclofenac/menthol topical: topical liquid.
Important warnings
This medicine can cause some serious health issues
Diclofenac and menthol can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Diclofenac and menthol may also cause stomach or intestinal bleeding, which can be fatal.
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Stop using this medicine and seek emergency medical attention if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
Also call your doctor at once if you have:
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a skin rash, no matter how mild;
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signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
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kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
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liver problems--nausea, diarrhea, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
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low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.
Serious side effects may be more likely in older adults.
Common side effects may include:
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skin dryness, redness, itching, or rash;
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blistering or hardening of the treated skin;
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numbness, tingling, burning pain;
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acne;
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flushing (sudden warmth, redness, or tingly feeling);
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stomach pain, constipation, diarrhea, gas, heartburn, nausea, vomiting; or
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dizziness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For healthcare professionals
Applies to diclofenac / menthol topical: topical liquid.
General
The most common adverse events reported with diclofenac sodium topical solution were application site skin reactions.[Ref]
Local
- Very common (10% or more): Dry skin (32%)
- Common (1% to 10%): Contact dermatitis (characterized by skin erythema and induration), contact dermatitis with vesicles and pruritus, application site pruritus
Application site reactions were reported as dryness, erythema, induration, vesicles, paresthesia, pruritus, vasodilation, acne, and urticaria.
Hematologic
- Common (1% to 10%): Ecchymosis
- Postmarketing reports: Rectal hemorrhage
Hypersensitivity
- Postmarketing reports: Allergic reaction
Respiratory
- Common (1% to 10%): Pharyngitis, sinusitis
- Postmarketing reports: Asthma, dyspnea, laryngismus, laryngitis
Gastrointestinal
- Common (1% to 10%): Dyspepsia, abdominal pain, flatulence, diarrhea, nausea, constipation, halitosis
- Postmarketing reports: Dry mouth, gastroenteritis, decreased appetite, mouth ulceration, ulcerative stomatitis
Musculoskeletal
- Postmarketing reports: Back pain, leg cramps, myalgia
Metabolic
- Postmarketing reports: Increased creatinine
Dermatologic
- Common (1% to 10%): Rash (non-application site), dry skin (non-application site)
- Postmarketing reports: Face edema, eczema, rash, pruritus, skin discoloration, urticaria
Psychiatric
- Postmarketing reports: Depression
Other
- Postmarketing reports: Asthenia, body odor, pain
Nervous system
- Common (1% to 10%): Paresthesia
- Postmarketing reports: Headache, neck rigidity, dizziness, drowsiness, lethargy
Cardiovascular
- Common (1% to 10%): Edema
- Postmarketing reports: Chest pain, palpitation, cardiovascular disorder
References
1. (2019) "Product Information. DicloStream (diclofenac-menthol topical)." UpStream Pharma LLC
More about DicloStream (diclofenac / menthol topical)
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- Drug class: topical non-steroidal anti-inflammatories
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Further information
DicloStream side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.