Dexmedetomidine Side Effects
Medically reviewed by Drugs.com. Last updated on Mar 3, 2022.
Commonly reported side effects of dexmedetomidine include: bradycardia, hypotension, agitation, hypertension, nausea, and tachycardia. Other side effects include: vomiting, and xerostomia. See below for a comprehensive list of adverse effects.
For the Consumer
A standardized concentration for this drug has been established through Standardize 4 Safety (S4S), a national patient safety initiative to reduce medication errors, especially during transitions of care. The drug is included in a standard concentration list which may apply to an IV or oral compounded liquid formulation. For additional information, see the ASHP website [Web].
Side effects include:
Short-term (<24 hours) infusions for ICU sedation: Hypotension, hypertension, nausea, bradycardia, fever, vomiting, hypovolemia, atelectasis, atrial fibrillation, hypoxia, tachycardia, hemorrhage, anemia, dry mouth.
Procedural sedation: Hypotension, respiratory depression, bradycardia, hypertension, tachycardia, nausea, dry mouth.
For Healthcare Professionals
Applies to dexmedetomidine: intravenous solution, sublingual film
Very common (10% or more): Hypotension (56%), bradycardia (42%), systolic hypertension (28%), hypotension requiring intervention (28%), tachycardia (25%), hypertension requiring intervention (19%), hypertension (16%), diastolic hypertension (12%), tachycardia requiring intervention (10%)
Common (1% to 10%): Atrial fibrillation, sinus tachycardia, myocardial ischemia or infarction, bradycardia requiring intervention
Uncommon (0.1% to 1%): Ventricular tachycardia, atrioventricular block first degree, decreased cardiac output
Frequency not reported: Sinus arrest
Postmarketing reports: Arrhythmia, cardiac arrest, cardiac disorder, extrasystoles, supraventricular tachycardia, ventricular arrhythmia, electrocardiogram T wave inversion, prolonged QT, blood pressure fluctuation, heart block[Ref]
Very common (10% or more): Respiratory depression (37%)
Uncommon (0.1% to 1%): Wheezing, dyspnea, apnea
Frequency not reported: Decreased respiratory rate
Postmarketing reports: Bronchospasm, hypercapnia, hypoventilation, pulmonary congestion, respiratory acidosis[Ref]
Very common (10% or more): Nausea (11%)
Common (1% to 10%): Decubitus ulcer
Uncommon (0.1% to 1%): Rash
Common (1% to 10%): Anemia
Uncommon (0.1% to 1%): Metabolic acidosis, hypoalbuminemia, electrolyte imbalance
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Ineffective drug
Frequency not reported: Tolerance, tachyphylaxis
Common (1% to 10%): Agitation, anxiety
Uncommon (0.1% to 1%): Hallucination
Postmarketing reports: Confusional state, delirium, illusion[Ref]
Common (1% to 10%): Acute renal failure, decreased urine output, oliguria
Postmarketing reports: Increased blood urea, polyuria[Ref]
Frequency not reported: Reduced lacrimation
Postmarketing reports: Photopsia, abnormal vision, visual impairment[Ref]
More about dexmedetomidine
- Drug interactions
- Dosage information
- During pregnancy or Breastfeeding
- Pricing & coupons
- En español
- Drug class: miscellaneous anxiolytics, sedatives and hypnotics
- Other brands
Related treatment guides
1. "Product Information. Precedex (dexmedetomidine)" Abbott Pharmaceutical, Abbott Park, IL.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.