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Dexferrum Side Effects

Generic name: iron dextran

Medically reviewed by Last updated on Feb 22, 2024.

Note: This document contains side effect information about iron dextran. Some dosage forms listed on this page may not apply to the brand name Dexferrum.

Applies to iron dextran: injection solution.


Injection route (Solution)

Anaphylactic-type reactions, including fatalities, have followed the parenteral use of iron dextran. Have resuscitation equipment and personnel readily available during administration. Administer a test dose, and only administer full dose in the absence of signs or symptoms of anaphylactic-type reaction. Observe patients during administration for anaphylactic-type reaction. Use iron dextran only in patients no amenable to oral iron therapy. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic reactions.

Serious side effects of Dexferrum

Along with its needed effects, iron dextran (the active ingredient contained in Dexferrum) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking iron dextran:

Incidence not known

Other side effects of Dexferrum

Some side effects of iron dextran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to iron dextran: injectable solution.


Uncommon (0.1% to 1%): Anaphylactoid reactions (including dyspnea, urticaria, rashes, itching, nausea, and shivering)

Very rare (less than 0.01%): Acute severe anaphylactoid reactions (sudden onset of respiratory difficulty and/or cardiovascular collapse)

Frequency not reported: Anaphylactic reactions, fatal anaphylactic reactions[Ref]


Uncommon (0.1% to 1%): Flushing, pruritus, rash

Rare (less than 0.1%): Angioedema, sweating

Frequency not reported: Urticaria, purpura[Ref]

Nervous system

Uncommon (0.1% to 1%): Numbness

Rare (less than 0.1%): Loss of consciousness, seizure, dizziness, tremor

Very rare (less than 0.01%): Headache, paresthesia

Frequency not reported: Convulsions, syncope, unresponsiveness, altered taste[Ref]


Uncommon (0.1% to 1%): Cramps

Rare (less than 0.1%): Myalgias

Frequency not reported: Arthralgia, exacerbation of joint pain, arthritis, backache[Ref]


Uncommon (0.1% to 1%): Feeling hot

Rare (0.01% to 0.1%): Fatigue, chest pain

Very rare (less than 0.01%): Transient deafness

Frequency not reported: Fever, weakness, febrile episodes, chills[Ref]


Uncommon (0.1% to 1%): Dyspnea

Frequency not reported: Respiratory arrest, bronchospasm, wheezing[Ref]


Uncommon (0.1% to 1%): Blurred vision[Ref]


Uncommon (0.1% to 1%): Nausea, emesis, abdominal pain

Rare (less than 0.1%): Diarrhea

Frequency not reported: Vomiting[Ref]


Rare (0.01 to 0.1%): Arrhythmia, tachycardia, hypotension

Very rare (less than 0.01%): Bradycardia, palpitations, hypertension

Frequency not reported: Chest tightness, shock, cyanosis, cardiac arrest[Ref]


Rare (less than 0.1%): Pain and brown pigmentation at injection site

Frequency not reported: Soreness or inflammation at or near injection site, local phlebitic reaction, staining of the skin, bleeding, formation of sterile abscesses, tissue necrosis, atrophy, pain, sterile abscess, cellulitis[Ref]


Very rare (less than 0.01%): Hemolysis

Frequency not reported: Leukocytosis, lymphadenopathy[Ref]


Rare (less than 0.1%): Restlessness, mental status changes

Frequency not reported: Disorientation[Ref]


Frequency not reported: Tumors at the injection site[Ref]


Frequency not reported: Hematuria[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. (2015) "Product Information. DexFerrum (iron dextran)." American Regent Laboratories Inc

3. "Product Information. Infed (iron dextran)." Schein Pharmaceuticals Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.