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Dexasone LA Side Effects

Generic name: dexamethasone

Medically reviewed by Drugs.com. Last updated on Oct 11, 2023.

Note: This document contains side effect information about dexamethasone. Some dosage forms listed on this page may not apply to the brand name Dexasone LA.

Applies to dexamethasone: oral elixir, oral solution, oral tablet.

Serious side effects of Dexasone LA

Along with its needed effects, dexamethasone (the active ingredient contained in Dexasone LA) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dexamethasone:

More common

Incidence not known

Other side effects of Dexasone LA

Some side effects of dexamethasone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Incidence not known

For Healthcare Professionals

Applies to dexamethasone: compounding powder, inhalation aerosol with adapter, injectable solution, injectable suspension, intravenous solution, oral concentrate, oral liquid, oral tablet.

General

The most commonly occurring side effects have included alteration in glucose tolerance, behavioral and mood changes, increased appetite, and weight gain; the incidence generally correlates with dosage, timing of administration, and duration of treatment.[Ref]

Psychiatric

A wide range of psychiatric reactions including affective disorders (e.g., irritable, euphoric, depressed, labile mood, and suicidal ideation) psychotic reactions (e.g., mania, delusions, hallucinations, aggravation of schizophrenia), behavioral disturbances, irritability, anxiety, sleep disturbances and cognitive dysfunction (e.g., confusion, amnesia) have been reported. These reactions have been reported in adults and children. In adults, the occurrence of severe reactions has been estimated to be about 5% to 6%.[Ref]

Frequency not reported: Depression, affective disorders, anxiety, emotional instability, euphoria, insomnia, mood swings, personality changes, psychic disorders, confusional states, anxiety, abnormal behavior, irritability, aggravated schizophrenia[Ref]

Nervous system

Frequency not reported: Convulsions, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, benign intracranial hypertension, neuropathy[Ref]

Gastrointestinal

Frequency not reported: Abdominal distention, nausea, pancreatitis, peptic ulcer, perforation of the small and large intestine, ulcerative esophagitis, gastric hemorrhage, vomiting, abdominal pain, diarrhea, dyspepsia, nausea, flatulence[Ref]

Hypersensitivity

Frequency not reported: Anaphylactoid reaction, anaphylaxis, angioedema[Ref]

Endocrine

Frequency not reported: Cushingoid state, hirsutism, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), moon face[Ref]

Metabolic

Frequency not reported: Decreased carbohydrate and glucose tolerance, hyperglycemia, glycosuria, manifestations of latent diabetes, hypokalemic alkalosis, potassium loss, sodium retention, increased appetite, negative nitrogen balance due to protein catabolism, weight gain, metabolic acidosis, hypercholesterolemia, hypertriglyceridemia, dyslipidemia[Ref]

Ocular

Frequency not reported: Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts, blindness, chorioretinopathy, worsening of symptoms associated with corneal ulcers, retinopathy of prematurity, blurred vision[Ref]

Rare instances of blindness have been associated with corticosteroid intralesional therapy around the face and head.[Ref]

Cardiovascular

Frequency not reported: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis, edema[Ref]

Musculoskeletal

Corticosteroids can cause a dose-dependent inhibition of growth in infancy, childhood, and adolescence due to it causing early closure of the epiphyses, which may be irreversible.[Ref]

Frequency not reported: Suppression of growth in pediatric patients, aseptic necrosis of femoral and humeral heads, calcinosis, Charcot-like atrophy, loss of muscle mass, muscle weakness, steroid myopathy. osteoporosis, pathologic fracture of long bones, postinjection flare, tendon rupture, particularly of the Achilles tendon, vertebral compression fractures, myalgia, muscle atrophy, osteonecrosis, neuropathic arthralgia, growth retardation[Ref]

Dermatologic

Frequency not reported: Acne, allergic dermatitis, dry scaly skin, ecchymosis, hirsutism, petechiae, erythema, hyperpigmentation, hypopigmentation, impaired wound healing, increased sweating, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria, hypertrichosis, angioedema, skin atrophy, hyperhidrosis, pruritus, burning or tingling especially in the perineal area (after IV injection), telangiectasia, pigment disorders[Ref]

Hematologic

Frequency not reported: Leucocytosis, lymphopenia, eosinopenia, polycythemia, abnormal coagulation, polymorphonuclear leukocytosis[Ref]

Genitourinary

Frequency not reported: Menstrual irregularities, amenorrhea, increased or decreased motility and number of spermatozoa, increased urine calcium[Ref]

Hepatic

Frequency not reported: Hepatomegaly, elevation in liver enzymes[Ref]

Immunologic

Frequency not reported: Opportunistic infection, exacerbation of latent infections, decreased resistance to infection, immunosuppression, candidiasis, chicken pox (varicella)

Other

Frequency not reported: Vertigo, abnormal fat deposits, malaise, sterile abscess, impaired healing, fatigue, malaise

Respiratory

Frequency not reported: Hiccups, pulmonary edema

Frequently asked questions

References

1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Product Information. Dexamethasone Sodium Phosphate (dexamethasone). West Ward Pharmaceutical Corporation. 2016.

3. Product Information. Dexamethasone (dexamethasone). Par Pharmaceutical Inc (formerly Qualitest Pharmaceuticals Inc). 2017.

4. Sechi GP, Piras MR, Demurtas A, Tanca S, Rosati G. Dexamethasone-induced schizoaffective-like state in multiple sclerosis: prophylaxis and treatment with carbamazepine. Clin Neuropharmacol. 1987;10:453-7.

5. Carroll BJ, Schroeder K, Mukhopadhyay S, Greden JF, Feinberg M, Ritchie J, Tarika J. Plasma dexamethasone concentrations and cortisol suppression response in patients with endogenous depression. J Clin Endocrinol Metab. 1980;51:433-7.

6. Product Information. Decadron (dexamethasone). Merck & Co., Inc. 2001;PROD.

7. Jaime Vazquez J. Persistent hiccup as a side-effect of dexamethasone treatment. Hum Exp Toxicol. 1993;12:52.

8. Kanwar AJ, Kaur S, Dhar S, Ghosh S. Hiccup--a side-effect of pulse therapy. Dermatology. 1993;187:279.

9. Fadul CE, Lemann W, Thaler HT, Posner JB. Perforation of the gastrointestinal tract in patients receiving steroids for neurologic disease. Neurology. 1988;38:348-52.

10. McDonnell M, Evans N. Upper and lower gastrointestinal complications with dexamethasone despite H2 antagonists. J Paediatr Child Health. 1995;31:152-4.

11. Whitmore SE. Dexamethasone injection-induced generalized dermatitis. Br J Dermatol. 1994;131:296-7.

12. New MI, Peterson RE, Saenger P, Levine LS. Evidence for an unidentified ACTH-induced steroid hormone causing hypertension. J Clin Endocrinol Metab. 1976;43:1283-93.

13. Spenney JG, Eure CA, Kreisberg RA. Hyperglycemic, hyperosmolar, nonketoacidotic diabetes. A complication of steroid and immunosupressive therapy. Diabetes. 1969;18:107-10.

14. Ludvik B, Clodi M, Kautzky-Willer A, Capek M, Hartter E, Pacini G, Prager R. Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans. Diabetologia. 1993;36:84-7.

15. Tsoi WW. Cushing's syndrome caused by analgesic/dexamethasone preparation. Ann Pharmacother. 1994;28:1411.

16. Kobayashi Y, Akaishi K, Nishio T, Kimura Y. Posterior subcapsular cataract in nephrotic children receiving steroid therapy. Am J Dis Child. 1974;128:671-3.

17. Bluming AZ, Zeegen P. Cataracts induced by intermittent Decadron used as an antiemetic. J Clin Oncol. 1986;4:221-3.

18. Godel V, Regenbogen L, Stein R. On the mechanism of corticosteroid-induced ocular hypertension. Ann Ophthalmol. 1978;10:191-6.

19. Francois J. Corticosteroid glaucoma. Ann Ophthalmol. 1977;9:1075-80.

20. Schmidt GB, Meier MA, Sadove MS. Sudden appearance of cardiac arrhythmias after dexamethasone. JAMA. 1972;221:1402-4.

21. Rao G, Zikria EA, Miller WH, Samadani SR, Ford WB. Cardiac arrhythmias after dexamethasone. JAMA. 1972;222:1185.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.