Denavir Side Effects

Generic name: penciclovir topical

Medically reviewed by Drugs.com. Last updated on Apr 21, 2025.

Note: This document provides detailed information about Denavir Side Effects associated with penciclovir topical. Some dosage forms listed on this page may not apply specifically to the brand name Denavir.

Applies to penciclovir topical: topical cream.

Common side effects of Denavir

Some side effects of penciclovir topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Denavir

Along with its needed effects, penciclovir topical (the active ingredient contained in Denavir) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking penciclovir topical:

For healthcare professionals

Applies to penciclovir topical: topical cream.

General adverse events

In clinical trials, 1 or more local side effects were reported by 3% of patients using penciclovir topical (the active ingredient contained in Denavir) and 4% of patients using placebo.^[Ref]

Local

• Common (1% to 10%): Application site reaction (including skin burning sensation, skin pain, hypoesthesia)
• Frequency not reported: Hypesthesia/local anesthesia, erythematous rash, taste perversion

Dermatologic

• Frequency not reported: Mild erythema
• Postmarketing reports: Allergic dermatitis (including rash, pruritus, blisters, edema), local edema, pain, paresthesia, pruritus, skin discoloration, urticaria, aggravated condition, decreased therapeutic response^[Ref]

Nervous system

• Postmarketing reports: Headache, parosmia^[Ref]

Hypersensitivity

• Postmarketing reports: Hypersensitivity^[Ref]

Other

• Postmarketing reports: Oral/pharyngeal edema^[Ref]

See also:

Further information

Denavir side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer