Skip to Content

Dalteparin Side Effects

In Summary

Commonly reported side effects of dalteparin include: pain at injection site. Other side effects include: hematoma at injection site and increased serum alanine aminotransferase. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dalteparin: subcutaneous injectable, subcutaneous solution

Along with its needed effects, dalteparin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dalteparin:

More Common

  • Deep, dark purple bruise, pain, or swelling at the injection site

Less Common

  • Bleeding of the gums
  • coughing up blood
  • difficulty with breathing or swallowing
  • dizziness
  • headache
  • increased menstrual flow or vaginal bleeding
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • unexplained pain, swelling, or discomfort, especially in the chest, abdomen or stomach, joints, or muscles
  • unusual bruising
  • vomiting of blood or material that looks like coffee grounds
  • weakness


  • Back pain
  • bleeding from mucous membranes
  • bluish or black discoloration, flushing, or redness of the skin
  • burning, pricking, tickling, or tingling sensation
  • coughing
  • feeling faint
  • fever
  • leg weakness
  • numbness
  • problems with bowel or bladder function
  • skin rash (which may consist of pinpoint, purple-red spots), hives, or itching
  • sloughing of the skin at the injection site
  • swelling of the eyelids, face, or lips
  • tightness in the chest

For Healthcare Professionals

Applies to dalteparin: subcutaneous solution


The most common side effects were any bleeding, postoperative transfusion, transaminase increases, and injection site pain.[Ref]


Very common (10% or more): Any bleeding (up to 18.5%)

Common (1% to 10%): Major bleeding reactions

Postmarketing reports: Prosthetic cardiac valve thrombosis[Ref]

A bleeding reaction was considered major if accompanied by a decrease in hemoglobin of 2 g/dL or greater in connection with clinical symptoms, a transfusion was required, bleeding led to interruption of treatment or death, bleeding caused a significant clinical event, bleeding resulted in reoperation, or retroperitoneal or intracranial bleeding occurred.[Ref]


Very common (10% or more): Postoperative transfusion (up to 15.9%)

Common (1% to 10%): Wound hematoma, reoperation due to bleeding[Ref]


Very common (10% or more): Grades 2 through 4 increases in AST and ALT (up to 14%)

Common (1% to 10%): Asymptomatic increases in transaminase levels (serum glutamic oxaloacetic transaminase/AST and Serum glutamic pyruvic transaminase/ALT) greater than 3 times the upper limit of normal, grades 3 and 4 increases in AST and ALT[Ref]

Nervous system

Postmarketing reports: Epidural/spinal hematoma, intracranial bleed[Ref]


Very common (10% or more): Injection site pain (up to 12%)

Common (1% to 10%): Injection site hematoma[Ref]


Common (1% to 10%): Reversible non-immunologically-mediated thrombocytopenia (type I)

Rare (less than 0.1%): Immunologically-mediated heparin-induced thrombocytopenia (type II, with or without associated thrombotic complications)[Ref]


Common (1% to 10%): Hematuria[Ref]


Uncommon (0.1% to 1%): Allergic reaction

Rare (less than 0.1%): Fever

Frequency not reported: Anaphylactoid reaction[Ref]


Uncommon (0.1% to 1%): Rash, urticaria, pruritus

Rare (less than 0.1%): Bullous eruptions, skin necrosis, alopecia[Ref]


Uncommon (0.1% to 1%): Hypersensitivity[Ref]


Uncommon (0.1% to 1%): Hyperkalemia[Ref]


Uncommon (0.1% to 1%): Osteoporosis[Ref]


Postmarketing reports: Hypoaldosteronism[Ref]


Frequency not reported: Gastrointestinal bleeding

Postmarketing reports: Retroperitoneal bleed[Ref]


Frequency not reported: Serum creatinine increased[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Fragmin (dalteparin)." Pharmacia and Upjohn, Kalamazoo, MI.

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.