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Cerezyme Side Effects

Generic name: imiglucerase

Medically reviewed by Last updated on Aug 3, 2020.

Note: This document contains side effect information about imiglucerase. Some of the dosage forms listed on this page may not apply to the brand name Cerezyme.

For the Consumer

Applies to imiglucerase: intravenous powder for solution

Side effects requiring immediate medical attention

Along with its needed effects, imiglucerase (the active ingredient contained in Cerezyme) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Side effects not requiring immediate medical attention

Some side effects of imiglucerase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abdominal discomfort
  • decrease in blood pressure, decrease in frequency of urination
  • dizziness
  • headache
  • itching
  • nausea
  • rash

For Healthcare Professionals

Applies to imiglucerase: intravenous powder for injection


Experience in patients treated with this drug have revealed that about 13.8% of patients experienced adverse events which were judged to be related to administration and included discomfort, pruritus, burning, swelling, or sterile abscess at the site of venipuncture.[Ref]


Common (1% to 10%): Discomfort, burning, swelling, sterile abscess

Frequency not reported: Pruritus[Ref]


Common (1% to 10%): Nausea, abdominal pain, vomiting, diarrhea

Uncommon (0.1% to 1%): Abdominal cramping[Ref]


Common (1% to 10%): Tachycardia

Uncommon (0.1% to 1%): Flushing, hypotension, cyanosis[Ref]


Common (1% to 10%): Hypersensitivity reaction

Rare (less than 0.1%): Anaphylactoid reaction[Ref]


Common (1% to 10%): Rash, urticaria, pruritus, angioedema[Ref]


Common (1% to 10%): Backache

Uncommon (0.1% to 1%): Arthralgia[Ref]


Common (1% to 10%): Dyspnea, coughing[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Paresthesia[Ref]


Common (1% to 10%): Fatigue, fever, chills

Uncommon (0.1% to 1%): Rigors

Frequency not reported: Chest discomfort, peripheral edema[Ref]


1. "Product Information. Cerezyme (imiglucerase)." Genzyme Corporation, Cambridge, MA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.