Skip to main content

Cerezyme Side Effects

Generic name: imiglucerase

Medically reviewed by Last updated on Nov 22, 2022.

Note: This document contains side effect information about imiglucerase. Some dosage forms listed on this page may not apply to the brand name Cerezyme.

Applies to imiglucerase: intravenous powder for solution.

Serious side effects of Cerezyme

Along with its needed effects, imiglucerase (the active ingredient contained in Cerezyme) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking imiglucerase:

Incidence not known

  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • blurred vision
  • chest pain, discomfort, or tightness
  • confusion
  • cough
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • feeling of warmth
  • fever or chills
  • headache
  • hives, itching, skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the face, neck, arms and occasionally, upper chest
  • sneezing
  • sore throat
  • sweating
  • trouble breathing
  • unusual tiredness or weakness

Other side effects of Cerezyme

Some side effects of imiglucerase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to imiglucerase: intravenous powder for injection.


Experience in patients treated with this drug have revealed that about 13.8% of patients experienced adverse events which were judged to be related to administration and included discomfort, pruritus, burning, swelling, or sterile abscess at the site of venipuncture.[Ref]


Common (1% to 10%): Discomfort, burning, swelling, sterile abscess

Frequency not reported: Pruritus[Ref]


Common (1% to 10%): Nausea, abdominal pain, vomiting, diarrhea

Uncommon (0.1% to 1%): Abdominal cramping[Ref]


Common (1% to 10%): Tachycardia

Uncommon (0.1% to 1%): Flushing, hypotension, cyanosis[Ref]


Common (1% to 10%): Hypersensitivity reaction

Rare (less than 0.1%): Anaphylactoid reaction[Ref]


Common (1% to 10%): Rash, urticaria, pruritus, angioedema[Ref]


Common (1% to 10%): Backache

Uncommon (0.1% to 1%): Arthralgia[Ref]


Common (1% to 10%): Dyspnea, coughing[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Paresthesia[Ref]


Common (1% to 10%): Fatigue, fever, chills

Uncommon (0.1% to 1%): Rigors

Frequency not reported: Chest discomfort, peripheral edema[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Cerezyme (imiglucerase)." Genzyme Corporation (2008):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.