Skip to Content

Calquence Side Effects

Generic Name: acalabrutinib

Note: This document contains side effect information about acalabrutinib. Some of the dosage forms listed on this page may not apply to the brand name Calquence.

For the Consumer

Applies to acalabrutinib: oral capsule

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • unusual bleeding (nose, mouth, vagina, or rectum), or any bleeding that will not stop;

  • signs of bleeding inside your body--dizziness, weakness, confusion, problems with speech, prolonged headache, black or bloody stools, pink or brown urine, or coughing up blood or vomit that looks like coffee grounds;

  • heart rhythm problems--chest pain, shortness of breath, pounding heartbeats or fluttering in your chest, feeling light-headed;

  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;

  • signs of infection--fever, chills, tiredness, flu-like symptoms, cough with mucus, chest pain, trouble breathing; or

  • signs of a serious brain infection--any change in your mental state, decreased vision, weakness on one side of your body, or problems with walking (may start gradually and get worse quickly).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • bruising;

  • headache;

  • muscle pain;

  • diarrhea; or

  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to acalabrutinib: oral capsule

General

The most common adverse reactions (reported incidence of 20% or greater) were anemia, thrombocytopenia, headache, neutropenia, diarrhea, fatigue, myalgia, and bruising.[Ref]

Cardiovascular

Very common (10% or more): Bleeding events (50%)
Common (1% to 10%): Hemorrhage/hematoma
Uncommon (0.1% to 1%): Atrial fibrillation, atrial flutter[Ref]

Hematologic

Very common (10% or more): Decreased hemoglobin (46%), decreased platelets (44%), decreased neutrophils (36%), neutropenia (23%), anemia (11%)
Common (1% to 10%): Thrombocytopenia[Ref]

Nervous system

Very common (10% or more): Headache (39%)[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (31%), nausea (19%), abdominal pain (15%), constipation (15%), vomiting (13%)[Ref]

Dermatologic

Very common (10% or more): Bruising/petechiae/ecchymosis/contusion (21%), rash (18%)[Ref]

Musculoskeletal

Very common (10% or more): Myalgia (21%)[Ref]

Oncologic

Very common (10% or more): Second primary malignancies (11%)
Common (1% to 10%): Skin cancer[Ref]

Hepatic

Common (1% to 10%): Increased creatinine[Ref]

Respiratory

Common (1% to 10%): Epistaxis
Frequency not reported: Pneumonia[Ref]

Other

Very common (10% or more): Fatigue (28%)
Frequency not reported: Infections[Ref]

References

1. "Product Information. Calquence (acalabrutinib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.

Some side effects of Calquence may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide