Calquence Side Effects
Generic Name: acalabrutinib
Note: This document contains side effect information about acalabrutinib. Some of the dosage forms listed on this page may not apply to the brand name Calquence.
For the Consumer
Applies to acalabrutinib: oral capsule
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
unusual bleeding (nose, mouth, vagina, or rectum), or any bleeding that will not stop;
signs of bleeding inside your body--dizziness, weakness, confusion, problems with speech, prolonged headache, black or bloody stools, pink or brown urine, or coughing up blood or vomit that looks like coffee grounds;
heart rhythm problems--chest pain, shortness of breath, pounding heartbeats or fluttering in your chest, feeling light-headed;
low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;
signs of infection--fever, chills, tiredness, flu-like symptoms, cough with mucus, chest pain, trouble breathing; or
signs of a serious brain infection--any change in your mental state, decreased vision, weakness on one side of your body, or problems with walking (may start gradually and get worse quickly).
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to acalabrutinib: oral capsule
The most common adverse reactions (reported incidence of 20% or greater) were anemia, thrombocytopenia, headache, neutropenia, diarrhea, fatigue, myalgia, and bruising.[Ref]
Very common (10% or more): Bleeding events (50%)
Common (1% to 10%): Hemorrhage/hematoma
Uncommon (0.1% to 1%): Atrial fibrillation, atrial flutter[Ref]
Very common (10% or more): Decreased hemoglobin (46%), decreased platelets (44%), decreased neutrophils (36%), neutropenia (23%), anemia (11%)
Common (1% to 10%): Thrombocytopenia[Ref]
Very common (10% or more): Headache (39%)[Ref]
Very common (10% or more): Diarrhea (31%), nausea (19%), abdominal pain (15%), constipation (15%), vomiting (13%)[Ref]
Very common (10% or more): Bruising/petechiae/ecchymosis/contusion (21%), rash (18%)[Ref]
Very common (10% or more): Myalgia (21%)[Ref]
Very common (10% or more): Second primary malignancies (11%)
Common (1% to 10%): Skin cancer[Ref]
Common (1% to 10%): Increased creatinine[Ref]
Common (1% to 10%): Epistaxis
Frequency not reported: Pneumonia[Ref]
Very common (10% or more): Fatigue (28%)
Frequency not reported: Infections[Ref]
1. "Product Information. Calquence (acalabrutinib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Some side effects of Calquence may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
More about Calquence (acalabrutinib)
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- Drug class: multikinase inhibitors
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