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Calquence Dosage

Generic name: ACALABRUTINIB 100mg
Dosage form: capsule, gelatin coated

Medically reviewed by Drugs.com. Last updated on Nov 29, 2017.

Recommended Dosage

The recommended dose of CALQUENCE is 100 mg taken orally approximately every twelve hours until disease progression or unacceptable toxicity.

Advise patients to swallow capsule whole with water. Advise patients not to open, break or chew the capsules. CALQUENCE may be taken with or without food. If a dose of CALQUENCE is missed by more than 3 hours, it should be skipped and the next dose should be taken at its regularly scheduled time. Extra capsules of CALQUENCE should not be taken to make up for a missed dose.

Dose Modifications

Adverse Reactions

Recommended dose modifications of CALQUENCE for Grade 3 or greater adverse reactions are provided in Table 1.

Table 1: Recommended Dose Modifications for Adverse Reactions

Event

Adverse Reaction Occurrence

Dose Modification

(Starting dose = 100 mg twice daily)

Grade 3 or greater non-hematologic toxicities,

Grade 3 thrombocytopenia with bleeding,

Grade 4 thrombocytopenia or

Grade 4 neutropenia lasting longer than 7 days

First and Second

Interrupt CALQUENCE.

Once toxicity has resolved to Grade 1 or baseline level, CALQUENCE therapy may be resumed at 100 mg twice daily.

Third

Interrupt CALQUENCE.

Once toxicity has resolved to Grade 1 or baseline level, CALQUENCE therapy may be resumed at 100 mg daily.

Fourth

Discontinue CALQUENCE.

Adverse reactions graded by the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4.03.

Dose Modifications for Use with CYP3A Inhibitors or Inducers

Recommended dose modifications are described below [see Drug Interactions (7)].

CYP3A

Co-administered Drug

Recommended CALQUENCE use

Inhibition

Strong CYP3A inhibitor

Avoid concomitant use.

If these inhibitors will be used short-term (such as anti-infectives for up to seven days), interrupt CALQUENCE.

Moderate CYP3A inhibitor

100 mg once daily.

Induction

Strong CYP3A inducer

Avoid concomitant use.

If these inducers cannot be avoided, increase CALQUENCE dose to 200 mg twice daily.

Concomitant Use with Gastric Acid Reducing Agents

Proton Pump Inhibitors: Avoid concomitant use [see Drug Interactions (7)].

H2-Receptor Antagonists: Take CALQUENCE 2 hours before taking a H2-receptor antagonist [see Drug Interactions (7)].

Antacids: Separate dosing by at least 2 hours [see Drug Interactions (7)].

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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