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Butalbital Side Effects

Applies to butalbital: compounding powder.

Nervous system

Nervous system side effects including drowsiness, lightheadedness, dizziness, sedation, and an intoxicated feeling have been reported frequently from the use of butalbital. Headache and seizures have been reported infrequently. Mental confusion, excitement, or depression have also been reported due to either intolerance (primarily in elderly or debilitated patients) or due to an overdosage of butalbital.[Ref]


Gastrointestinal side effects including nausea, vomiting, and abdominal pain have been reported frequently with the use of butalbital.[Ref]


Respiratory side effects including dyspnea have been reported frequently with the use of butalbital.[Ref]


1. "Product Information. Fioricet (acetaminophen/butalbital/caffeine)." Novartis Pharmaceuticals (2022):

2. "Product Information. Fioricet with Codeine (acetaminophen/butalbital/caffeine/codeine)." Novartis Pharmaceuticals (2022):

3. "Product Information. Fiorinal with Codeine (aspirin/butalbital/caffeine/codeine)." Novartis Pharmaceuticals (2022):

4. "Product Information. Fiorinal (aspirin/butalbital/caffeine)." Actavis (formerly Abrika Pharmaceuticals LLP) (2022):

5. "Product Information. Sedapap (acetaminophen-butalbital)." Merz Pharmaceuticals (2001):

6. "Product Information. Esgic-Plus (acetaminophen/butalbital/caffeine)." Forest Pharmaceuticals (2022):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.