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Butalbital use while Breastfeeding

Medically reviewed by Last updated on May 23, 2022.

Drugs containing Butalbital: Fioricet, Butalbital Compound, Fiorinal, Triad, Esgic, Fioricet with Codeine, Tencon, Phrenilin, Bupap, Fiorinal with Codeine, Show all 70 »Anoquan, Ascomp with Codeine, Fiorinal with Codeine III, Promacet, Isocet, Endolor, Axotal, Fortabs, Laniroif, Phrenilin Forte (old formulation), Orbivan CF, Allzital, Triaprin, Bucet, Sedapap, Dolgic, Marten-Tab, Prominol, Cephadyn, Butex Forte, Axocet, Phrenilin Forte, Alagesic LQ, Vtol LQ, Vanatol LQ, Arcet, Pharmagesic, Two-Dyne, Tenake, Margesic, Anolor 300, Femcet, Geone, Tencet, Fiorpap, Repan, Dolmar, Ezol, Ide-cet, G-1, Medigesic, Minotal, Mygracet, Pacaps, Alagesic, Americet, Zebutal, Nonbac, Vanatol S, Dolgic Plus, Esgic-Plus, Dolgic LQ, Capacet, Orbivan, Phrenilin with Caffeine and Codeine, Fiormor, Fiortal, Idenal, Farbital, Fiortal with Codeine

Butalbital Levels and Effects while Breastfeeding

Summary of Use during Lactation

Butalbital in breastmilk has caused poor feeding and vomiting in one infant. Other agents are preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. A 7-day-old breastfed infant's urine was qualitatively positive for barbiturate after his mother took a combination of butalbital 50 mg with acetaminophen 325 mg and caffeine 50 mg every 6 hours for 24 hours.[1]

Effects in Breastfed Infants

The mother of a newborn took a product containing acetaminophen 325 mg, butalbital 50 mg, and caffeine 40 mg every 6 hours for 24 hours for a spinal headache, with the last dose a day prior to presentation at the emergency department. Her 7-day-old infant had a history of 1 to 2 days of poor feeding, lethargy and vomiting. The infant was somnolent, lethargic, and demonstrating diminished reflexes. The urine was qualitatively positive for barbiturate and had also had 1 mg/L of caffeine 15 hours after hospital admission. The infant's symptoms resolved within 24 hours. The symptoms were probably caused by butalbital.[1]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.


Vohra V, Marraffa JM. Maternal use of acetaminophen-butalbital-caffeine product resulting in neonate butalbital exposure through breast milk. Clin Toxicol. 2019;57:549. Abstract. DOI: 10.1080/15563650.2019.1598646. [CrossRef]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

  • Breast Feeding
  • Lactation
  • Barbiturates
  • GABA Modulators
  • Hypnotics and Sedatives

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Further information

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