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Brimonidine topical Side Effects

Medically reviewed by Last updated on Feb 11, 2022.


Commonly reported side effects of brimonidine topical include: flushing. Other side effects include: burning sensation of skin and erythema of skin. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to brimonidine topical: topical application gel/jelly

Side effects requiring immediate medical attention

Along with its needed effects, brimonidine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brimonidine topical:

More common

  • Flushing or redness of the skin
  • unusually warm skin

Less common

  • Blemishes on the skin
  • blistering, burning, crusting, dryness, or flaking of the skin
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • pimples

Side effects not requiring immediate medical attention

Some side effects of brimonidine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • fever
  • headache
  • muscle aches
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to brimonidine topical: topical gel


The most commonly reported adverse reactions are headache, erythema, pruritus, flushing and skin burning sensation.[Ref]


Common (1% to 10%): Acne, allergic contact dermatitis, contact dermatitis, dermatitis, erythema, pruritus, rosacea, skin burning sensation, skin irritation, skin pain, warm skin

Uncommon (0.1% to 1%): Dry skin, skin discomfort, papular rash

Postmarketing reports: Aggravated erythema, face swelling, pallor, urticaria[Ref]


Common (1% to 10%): Nasal congestion, nasopharyngitis, upper respiratory track infection

Postmarketing reports: Throat tightness[Ref]


Common (1% to 10%): Blurred vision, increased intraocular pressure

Uncommon (0.1% to 1%): Eyelid edema[Ref]

Nervous system

Common (1% to 10%): Headache, paresthesia

Postmarketing reports: Dizziness[Ref]


Common (1% to 10%): Flushing

Postmarketing reports: Bradycardia, hypotension, orthostatic hypotension[Ref]


Uncommon (0.1% to 1%): Feeling hot, peripheral coldness[Ref]


Uncommon (0.1% to 1%): Dry mouth

Postmarketing reports: Lip swelling, tongue swelling[Ref]


Postmarketing reports: Angioedema, hypersensitivity[Ref]


Postmarketing reports: Application site pallor, excessive whitening at application site[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Mirvaso (brimonidine topical)." Galderma Laboratories Inc (2013):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.