Blenrep Side Effects

Generic name: belantamab mafodotin

Medically reviewed by Drugs.com. Last updated on Nov 12, 2024.

Note: This document provides detailed information about Blenrep Side Effects associated with belantamab mafodotin. Some dosage forms listed on this page may not apply specifically to the brand name Blenrep.

Applies to belantamab mafodotin: intravenous powder for solution.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine to make sure that it is working properly. Blood tests may be needed to check for unwanted effects. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor) before or during treatment.

Receiving this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Use an effective form of birth control while you are receiving this medicine and for at least 4 months after the last dose to keep from getting pregnant. Males who are taking this medicine, with female partners who can become pregnant, must use effective birth control during and for at least 6 months after the last dose of this medicine. If you think you have become pregnant while receiving the medicine, tell your doctor right away.

This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

Check with your doctor immediately if blurred vision or any other change in vision, difficulty in reading, dry eyes, or eye redness, irritation, or pain occurs during or after treatment. These may be symptoms of a serious eye problem (eg, ocular toxicity). Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

This medicine will lower the number of some types of blood cells in your body. Because of this, you may bleed more easily. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

This medicine may cause infusion-related reactions, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chill or shaking, dizziness, headache, trouble breathing, itching or skin rash, lightheadedness, fainting, or fast, pounding, or uneven heartbeat after receiving this medicine.

Serious side effects of Blenrep

Along with its needed effects, belantamab mafodotin (the active ingredient contained in Blenrep) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking belantamab mafodotin:

Other side effects of Blenrep

Some side effects of belantamab mafodotin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to belantamab mafodotin: intravenous powder for injection.

General adverse events

This drug caused serious adverse reactions in 40% of patients. Serious adverse reactions in 3% or more of patients included pneumonia (7%), pyrexia (6%), renal impairment (4%), sepsis (4%), hypercalcemia (4%), and infusion-related reactions (3%). Fatal adverse reactions occurred in 3.2% of patients, including sepsis (1%), cardiac arrest (1%), and lung infection (1%).^[Ref]

Hematologic

• Very common (10% or more): Thrombocytopenia (69% all Grades, 13% Grade 2, 10% Grade 3, 17% Grade 4), platelets decreased (62%), lymphocytes decreased (49%), hemoglobin decreased (32%), neutrophils decreased (28%)^[Ref]

Immunologic

• Frequency not reported: Potential for immunogenicity^[Ref]

Local

• Very common (10% or more): Infusion related reactions (IRRs) (e.g., infusion-related reaction, pyrexia, chills, diarrhea, nausea, asthenia, hypertension, lethargy, tachycardia) (21%)^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (12%), back pain (11%)^[Ref]

Metabolic

• Very common (10% or more): Albumin decreased (43%), glucose increased (38%), sodium decreased (21%), potassium decreased (20%), anorexia (12%)^[Ref]

Genitourinary

• Common (1% to 10%): Albuminuria^[Ref]

Hepatic

• Very common (10% or more): Aspartate aminotransferase increased (57%), alkaline phosphatase increased (26%), gamma-glutamyl transferase increased (25%)^[Ref]

Respiratory

• Very common (10% or more): Upper respiratory tract infection (e.g., upper respiratory tract infection, nasopharyngitis, rhinovirus infections, sinusitis (11%)
• Common (1% to 10%): Pneumonia^[Ref]

Other

• Very common (10% or more): Pyrexia (22%), fatigue/asthenia (20%)^[Ref]

Ocular

• Very common (10% or more): Ocular adverse reactions (77%), keratopathy (based on slit lamp eye examination and characterized as corneal epithelium changes with or without symptoms) (76% all Grades; 44% Grade 3 or 4), decreased visual acuity (53% all Grades; 28% Grade 3 or 4), blurred vision (e.g., diplopia, vision blurred, visual acuity reduced, visual impairment (22% all Grades; 4% Grade 3 or 4), dry eye (e.g., dry eye, ocular discomfort, eye pruritus) (14% all Grades 1% Grade 3 or 4)
• Common (1% to 10%): Photophobia, eye irritation, infective keratitis, ulcerative keratitis^[Ref]

Renal

• Very common (10% or more): Creatinine increased/creatinine phosphokinase increased (22%)^[Ref]

Cardiovascular

• Very common (10% or more): Infusion related tachycardia^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (24%), constipation (13%), diarrhea (13%)
• Common (1% to 10%): Vomiting^[Ref]

See also:

Further information

Blenrep side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer