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Biperiden Side Effects

Medically reviewed by Last updated on Dec 31, 2022.

Applies to biperiden: oral tablet.


Use caution when driving, operating machinery, or performing other hazardous activities. Biperiden may cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking biperiden.

Avoid becoming overheated. Biperiden may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise.

If you experience any of the following serious side effects, stop taking biperiden and seek emergency medical attention:

Other, less serious side effects may be more likely to occur. Continue to take biperiden and talk to your doctor if you experience

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

For Healthcare Professionals

Applies to biperiden: oral tablet.

Nervous system

Nervous system side effects have included drowsiness, choreic movements, reduced rapid eye movement sleep, and anticholinergic syndrome. Symptoms of central anticholinergic syndrome include: dilated, sluggish pupils; warm, dry skin; flushing; decreased respiratory tract secretions; foul breath; increased body temperature; decrease bowel sounds; urinary retention; tachycardia/cardiac arrhythmias;delirium, disorientation, anxiety, hallucinations, confusion, incoherence; agitation; hyperactivity, ataxia, loss of memory; paranoia; combativeness and seizures. Central anticholinergic syndrome may progress to stupor, coma, paralysis, cardiac/respiratory arrest and death. Orthostatic dizziness, hypokinesia, and headache have also been reported.[Ref]

A case of choreic movements was reported in a patient on concomitant therapy of biperiden and carbidopa/levodopa.[Ref]


Gastrointestinal side effects have included dry mouth, constipation, gastric irritation, nausea, vomiting, and increased salivation.[Ref]


Psychiatric side effects have included euphoria, disorientation, agitation, disturbed behavior, and concentration difficulties.[Ref]


Other side effects have included asthenia.[Ref]


Hypersensitivity side effects have included allergic skin reactions.[Ref]


Genitourinary side effects have included urinary retention.[Ref]


Ocular side effects have included blurred vision.[Ref]


Cardiovascular side effects have included postural hypotension and bradycardia when administered parenterally.[Ref]

Postural hypotension and bradycardia may be minimized or eliminated by slow intravenous administration.[Ref]


1. (2008) "Product Information. Akineton HCl (biperiden)." Par Pharmaceutical Inc

2. Baskak B, Atbasoglu EC, Ozguven HD, Saka MC, Gogus AK (2007) "The effectiveness of intramuscular biperiden in acute akathisia: a double-blind, randomized, placebo-controlled study." J Clin Psychopharmacol, 27, p. 289-94

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.