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Biperiden Side Effects

Medically reviewed by Last updated on Aug 15, 2022.

Applies to biperiden: oral tablet.

Nervous system

Nervous system side effects have included drowsiness, choreic movements, reduced rapid eye movement sleep, and anticholinergic syndrome. Symptoms of central anticholinergic syndrome include: dilated, sluggish pupils; warm, dry skin; flushing; decreased respiratory tract secretions; foul breath; increased body temperature; decrease bowel sounds; urinary retention; tachycardia/cardiac arrhythmias;delirium, disorientation, anxiety, hallucinations, confusion, incoherence; agitation; hyperactivity, ataxia, loss of memory; paranoia; combativeness and seizures. Central anticholinergic syndrome may progress to stupor, coma, paralysis, cardiac/respiratory arrest and death. Orthostatic dizziness, hypokinesia, and headache have also been reported.[Ref]

A case of choreic movements was reported in a patient on concomitant therapy of biperiden and carbidopa/levodopa.[Ref]


Gastrointestinal side effects have included dry mouth, constipation, gastric irritation, nausea, vomiting, and increased salivation.[Ref]


Psychiatric side effects have included euphoria, disorientation, agitation, disturbed behavior, and concentration difficulties.[Ref]


Other side effects have included asthenia.[Ref]


Hypersensitivity side effects have included allergic skin reactions.[Ref]


Genitourinary side effects have included urinary retention.[Ref]


Ocular side effects have included blurred vision.[Ref]


Postural hypotension and bradycardia may be minimized or eliminated by slow intravenous administration.[Ref]

Cardiovascular side effects have included postural hypotension and bradycardia when administered parenterally.[Ref]


1. "Product Information. Akineton HCl (biperiden)." Par Pharmaceutical Inc (2008):

2. Baskak B, Atbasoglu EC, Ozguven HD, Saka MC, Gogus AK "The effectiveness of intramuscular biperiden in acute akathisia: a double-blind, randomized, placebo-controlled study." J Clin Psychopharmacol 27 (2007): 289-94

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.