Bexxar Dosimetric Side Effects

Generic name: tositumomab

Note: This document contains side effect information about tositumomab. Some dosage forms listed on this page may not apply to the brand name Bexxar Dosimetric.

Applies to tositumomab: intravenous solution.

Serious side effects of Bexxar Dosimetric

Along with its needed effects, tositumomab (the active ingredient contained in Bexxar Dosimetric) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking tositumomab:

More common

• Bleeding gums
• bloating or swelling of the face, arms, hands, lower legs, or feet
• blurred vision
• bone pain
• chest pain
• chills
• confusion
• constipation
• cough
• coughing up blood
• depressed mood
• difficulty with breathing
• difficulty with swallowing
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry skin and hair
• fast heartbeat
• feeling cold
• fever or chills
• hair loss
• headache
• hives
• hoarseness or husky voice
• increased menstrual flow or vaginal bleeding
• itching
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• lower back or side pain
• muscle cramps and stiffness
• noisy breathing
• nosebleeds
• painful or difficult urination
• pale skin
• paralysis
• pinpoint red spots on the skin
• prolonged bleeding from cuts
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rapid weight gain
• red or black, tarry stools
• red or dark brown urine
• shortness of breath
• skin rash
• slowed heartbeat
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• sweating
• swollen glands
• tightness in the chest
• tingling of the hands or feet
• troubled breathing with exertion
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight gain or loss
• wheezing

Less common

• Feeling of warmth or heat
• flushing or redness of the skin, especially on the face and neck

Other side effects of Bexxar Dosimetric

Some side effects of tositumomab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach
• back pain
• belching
• body aches or pain
• congestion
• diarrhea or increased bowel movements
• difficult or labored breathing
• difficulty with moving
• dryness or soreness of the throat
• heartburn
• indigestion
• itching skin
• joint pain
• lack or loss of strength
• loose or liquid stools
• loss of appetite
• muscle aches or pains
• nausea or feeling of upset stomach or feeling like you may vomit
• neck pain
• runny nose
• stomach discomfort, upset, or pain
• sudden sweating
• swelling of the hands, ankles, feet, or lower legs
• swollen joints
• tender, swollen glands in the neck
• trouble with swallowing
• voice changes
• vomiting
• weight loss

Less common

• Sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to tositumomab: intravenous kit.

Cardiovascular

Common (1% to 10%): Hypotension, vasodilation^[Ref]

Dermatologic

Very common (10% or more): Rash, pruritus

Common (1% to 10%): Sweating^[Ref]

Endocrine

Common (1% to 10%): Hypothyroidism^[Ref]

Gastrointestinal

Very common (10% or more): Abdominal pain, nausea, vomiting, diarrhea, anorexia

Common (1% to 10%): Constipation, dyspepsia^[Ref]

Hematologic

Very common (10% or more): Neutropenia, thrombocytopenia, anemia^[Ref]

Hypersensitivity

Common (1% to 10%): Allergic (hypersensitivity) reactions (allergic reaction, facial edema, injection site hypersensitivity, anaphylactic reaction, laryngismus, serum sickness)

Postmarketing reports: Hypersensitivity reactions including fatal anaphylaxis^[Ref]

Immunologic

Very common (10% or more): Positive serology for human anti-mouse antibodies (HAMA)^[Ref]

Local

Frequency not reported: Infusion reactions^[Ref]

Metabolic

Common (1% to 10%): Peripheral edema, weight loss^[Ref]

Musculoskeletal

Very common (10% or more): Myalgia, arthralgia

Common (1% to 10%): Back pain, neck pain^[Ref]

Nervous system

Common (1% to 10%): Dizziness, somnolence

Postmarketing reports: Axonal neuropathy leading to quadriparesis^[Ref]

Oncologic

Common (1% to 10%): Secondary malignancies (non-melanoma skin, colorectal, head and neck, breast, lung, bladder, melanoma, gastric)

Frequency not reported: Secondary leukemia, myelodysplastic syndrome^[Ref]

Other

Very common (10% or more): Asthenia, fever, infections, pain, chills, headache

Common (1% to 10%): Chest pain, serious infections (pneumonia, bacteremia, septicemia, bronchitis, skin infections)^[Ref]

Respiratory

Very common (10% or more): Cough, pharyngitis, dyspnea, rhinitis

Common (1% to 10%): Pneumonia^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer