Benzocaine / Dextromethorphan / Menthol Topical Side Effects
Applies to benzocaine/dextromethorphan/menthol topical: mucous membrane lozenge.
Hypersensitivity
Benzocaine:
- Frequency not reported: Angioedema
- Rare (less than 0.1%): Fixed-drug eruptions
- Frequency not reported: Angioedema[Ref]
Dermatologic
Benzocaine:
- Frequency not reported: Contact dermatitis, urticaria
Dextromethorphan:
Local
Benzocaine:
- Frequency not reported: Burning, stinging
- Frequency not reported: Application site redness/irritation[Ref]
Gastrointestinal
Dextromethorphan:
- Frequency not reported: Abdominal pain, diarrhea, gastrointestinal disturbance, nausea, upset stomach, vomiting[Ref]
Psychiatric
Dextromethorphan:
Nervous system
Dextromethorphan:
- Frequency not reported: Convulsions, dizziness, drowsiness[Ref]
Hematologic
Benzocaine:
- Postmarketing reports: Methemoglobinemia[Ref]
Respiratory
Dextromethorphan:
- Frequency not reported: Respiratory depression[Ref]
Cardiovascular
Benzocaine:
References
1. Stubb S, Reitamo S (1990) "Fixed-drug eruption due to dextromethorphan ." Arch Dermatol, 126, p. 970-1
2. Hall RC, Beresford TP, Stickney SK, Nasdahl CS, Coleman JH (1985) "Psychiatric reactions produced by respiratory drugs." Psychosomatics, 26, 605-8,616-7
3. Helfer J, Kim OM (1990) "Psychoactive abuse potential of Robitussin-DM." Am J Psychiatry, 147, p. 672-3
4. Murray S, Brewerton T (1993) "Abuse of over-the-counter dextromethorphan by teenagers." South Med J, 86, p. 1151-3
5. Wolfe TR, Caravati EM (1995) "Massive dextromethorphan ingestion and abuse." Am J Emerg Med, 13, p. 174-6
6. Polles A, Griffith JL (1996) "Dextromethorphan-induced mania." Psychosomatics, 37, p. 71-4
7. Bostwick JM (1996) "Dextromethorphan-induced manic symptoms in a bipolar patient on lithium." Psychosomatics, 37, p. 571-2
8. Knowles SR, Weber E (1998) "Dextromethorphan anaphylaxis." J Allerg Clin Immunol, 102, p. 316-7
9. (2003) "Product Information. Stopain (menthol topical)." DRJ Group Inc
10. "Product Information. Cold and Hot (menthol topical)." Major Pharmaceuticals Inc
11. (2004) "Product Information. BENGAY Pain Relieving (menthol topical)." Pfizer U.S. Pharmaceuticals Group
12. (2005) "Product Information. Solarcaine Plus Aloe (benzocaine topical)." Schering-Plough Healthcare Products
13. (2005) "Product Information. Americaine Hemorrhoidal (benzocaine topical)." Novartis Consumer Health
14. (2005) "Product Information. Dermoplast (benzocaine topical)." MedTech Inc
15. (2005) "Product Information. Outgro Pain Relief (benzocaine topical)." MedTech Inc
16. (2005) "Product Information. Cepacol Lozenges (cetylpyridinium topical)." GlaxoSmithKline Inc
17. (2005) "Product Information. Chloraseptic (benzocaine topical)." Procter and Gamble Pharmaceuticals
18. (2005) "Product Information. Vagisil Feminine Cream (benzocaine topical)." Combe Inc
19. (2005) "Product Information. Lanacane (benzocaine topical)." Combe Inc
20. (2005) "Product Information. Hurricaine (benzocaine topical)." Beutlich
21. Cerner Multum, Inc. "UK Summary of Product Characteristics."
22. Throm MJ, Stevens MD, Hansen C (2007) "Benzocaine-induced methemoglobinemia in two patients: interdisciplinary collaboration, management, and near misses." Pharmacotherapy, 27, p. 1206-14
More about benzocaine / dextromethorphan / menthol topical
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Further information
Benzocaine/dextromethorphan/menthol topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.