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Benzocaine / dextromethorphan / menthol Side Effects

Applies to benzocaine/dextromethorphan/menthol: mucous membrane lozenge

Hypersensitivity

Benzocaine:
Frequency not reported: Angioedema

Dextromethorphan:
Rare (less than 0.1%): Fixed-drug eruptions
Frequency not reported: Angioedema[Ref]

Dermatologic

Benzocaine:
Frequency not reported: Contact dermatitis, urticaria

Dextromethorphan:
Frequency not reported: Pruritus, rash, urticaria[Ref]

Local

Benzocaine:
Frequency not reported: Burning, stinging

Menthol:
Frequency not reported: Application site redness/irritation[Ref]

Gastrointestinal

Dextromethorphan:
Frequency not reported: Abdominal pain, diarrhea, gastrointestinal disturbance, nausea, upset stomach, vomiting[Ref]

Psychiatric

Dextromethorphan:
Frequency not reported: Abuse, excitation, insomnia, mental confusion[Ref]

Nervous system

Dextromethorphan:
Frequency not reported: Convulsions, dizziness, drowsiness[Ref]

Hematologic

Benzocaine:
Postmarketing reports: Methemoglobinemia[Ref]

Respiratory

Dextromethorphan:
Frequency not reported: Respiratory depression[Ref]

Cardiovascular

Benzocaine:
Frequency not reported: Edema[Ref]

References

1. Stubb S, Reitamo S "Fixed-drug eruption due to dextromethorphan ." Arch Dermatol 126 (1990): 970-1

2. "Product Information. Cepacol Lozenges (cetylpyridinium topical)." GlaxoSmithKline Inc, Oakville, IA.

3. "Product Information. Lanacane (benzocaine topical)." Combe Inc, White Plains, NY.

4. "Product Information. Cold & Hot (menthol topical)." Major Pharmaceuticals Inc, Livonia, MI.

5. "Product Information. Chloraseptic (benzocaine topical)." Procter and Gamble Pharmaceuticals, Mason, OH.

6. "Product Information. Solarcaine Plus Aloe (benzocaine topical)." Schering-Plough Healthcare Products, Memphis, TN.

7. "Product Information. Vagisil Feminine Cream (benzocaine topical)." Combe Inc, White Plains, NY.

8. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

9. "Product Information. Outgro Pain Relief (benzocaine topical)." MedTech Inc, Irvington, NY.

10. "Product Information. Dermoplast (benzocaine topical)." MedTech Inc, Irvington, NY.

11. Bostwick JM "Dextromethorphan-induced manic symptoms in a bipolar patient on lithium." Psychosomatics 37 (1996): 571-2

12. Wolfe TR, Caravati EM "Massive dextromethorphan ingestion and abuse." Am J Emerg Med 13 (1995): 174-6

13. "Product Information. BENGAY Pain Relieving (menthol topical)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

14. Hall RC, Beresford TP, Stickney SK, Nasdahl CS, Coleman JH "Psychiatric reactions produced by respiratory drugs." Psychosomatics 26 (1985): 605-8,616-7

15. Throm MJ, Stevens MD, Hansen C "Benzocaine-induced methemoglobinemia in two patients: interdisciplinary collaboration, management, and near misses." Pharmacotherapy 27 (2007): 1206-14

16. Knowles SR, Weber E "Dextromethorphan anaphylaxis." J Allerg Clin Immunol 102 (1998): 316-7

17. Helfer J, Kim OM "Psychoactive abuse potential of Robitussin-DM." Am J Psychiatry 147 (1990): 672-3

18. Polles A, Griffith JL "Dextromethorphan-induced mania." Psychosomatics 37 (1996): 71-4

19. "Product Information. Stopain (menthol topical)." DRJ Group Inc, Carlsbad, CA.

20. Murray S, Brewerton T "Abuse of over-the-counter dextromethorphan by teenagers." South Med J 86 (1993): 1151-3

21. "Product Information. Americaine Hemorrhoidal (benzocaine topical)." Novartis Consumer Health, Parsippany, NJ.

22. "Product Information. Hurricaine (benzocaine topical)." Beutlich, Waukegan, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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