Atropine / Difenoxin Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 30, 2024.

Applies to atropine / difenoxin: oral tablet.

Other side effects

Some side effects of atropine / difenoxin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare side effects

• blurred vision
• confusion
• difficult urination
• dizziness or lightheadedness
• drowsiness
• dryness of skin and mouth
• fever
• headache
• trouble in sleeping
• unusual tiredness or weakness

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, Check with your doctor immediately if you notice the following side effects:

• increased sweating
• muscle cramps
• nausea or vomiting
• shivering or trembling
• stomach cramps

Serious side effects

Along with its needed effects, atropine/difenoxin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking atropine / difenoxin:

• Bloating
• constipation
• loss of appetite
• stomach pain (severe) with nausea and vomiting

Get emergency help immediately if any of the following symptoms of overdose occur while taking atropine / difenoxin:

• Blurred vision (continuing) or changes in near vision
• drowsiness (severe)
• dryness of mouth, nose, and throat (severe)
• fast heartbeat
• shortness of breath or troubled breathing (severe)
• unusual excitement, nervousness, restlessness, or irritability
• unusual warmth, dryness, and flushing of skin

For healthcare professionals

Applies to atropine / difenoxin: oral tablet.

Gastrointestinal adverse events

• Common (1% to 10%): Vomiting, dry mouth, epigastric distress
• Uncommon (0.1% to 1%): Constipation^[Ref]

Nervous system

• Common (1% to 10%): Dizziness and light-headedness, drowsiness, headache
• Uncommon (0.1% to 1%): Tiredness, nervousness, insomnia, confusion^[Ref]

Ocular

• Frequency not reported: Burning eyes, blurred vision^[Ref]

Further information

Atropine/difenoxin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer