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Atropine / difenoxin Side Effects

For the Consumer

Applies to atropine / difenoxin: oral tablet

Along with its needed effects, atropine/difenoxin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking atropine/difenoxin:

Get emergency help immediately if any of the following symptoms of overdose occur while taking atropine / difenoxin:

  • Blurred vision (continuing) or changes in near vision
  • drowsiness (severe)
  • dryness of mouth, nose, and throat (severe)
  • fast heartbeat
  • shortness of breath or troubled breathing (severe)
  • unusual excitement, nervousness, restlessness, or irritability
  • unusual warmth, dryness, and flushing of skin

Some side effects of atropine / difenoxin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare
  • Blurred vision
  • confusion
  • difficult urination
  • dizziness or lightheadedness
  • drowsiness
  • dryness of skin and mouth
  • fever
  • headache
  • trouble in sleeping
  • unusual tiredness or weakness

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Increased sweating
  • muscle cramps
  • nausea or vomiting
  • shivering or trembling
  • stomach cramps

For Healthcare Professionals

Applies to atropine / difenoxin: oral tablet


Gastrointestinal side effects have included nausea (1 in 15 patients), vomiting (1 in 30 patients), dry mouth (1 in 30 patients), epigastric distress (1 in 100 patients), and constipation ( 1 in 300 patients).

In patients receiving chemically-related drugs, toxic megacolon, paralytic ileus, pancreatitis, and anorexia have been reported.[Ref]


Cardiovascular side effects have included tachycardia with the use of atropine.[Ref]

Nervous system

Nervous system side effects have included dizziness (1 in 20 patients), lightheadedness (1 in 20 patients), drowsiness (1 in 25 patients), headache (1 in 40 patients). Other less common side effects have included tiredness and insomnia.

Patients receiving chemically-related drugs have reported confusion, numbness of extremities, euphoria, depression, and sedation.[Ref]


Hypersensitivity side effects have included anaphylaxis, angioneurotic edema, urticaria, swelling of the gums, and pruritus.[Ref]


Ocular side effects have included burning eyes and blurred vision.[Ref]


General side effects reported with use of atropine have included flushing and hyperthermia.[Ref]


Genitourinary side effects have included urinary retention with use of atropine.[Ref]


1. "Product Information. Motofen (atropine-difenoxin)." Carnrick Laboratories Inc, Cedar Knolls, NJ.

Some side effects of atropine / difenoxin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.