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Aspirin / codeine Side Effects

Applies to aspirin/codeine: oral tablet

General

The more commonly reported adverse reactions have included nausea, dyspepsia, constipation, drowsiness, dizziness, and tinnitus.[Ref]

Gastrointestinal

Frequency not reported: Nausea, dyspepsia, vomiting, constipation, dry mouth, gastrointestinal bleeding or ulceration, biliary spasm, loss of appetite, paralytic ileus or toxic megacolon[Ref]

Nervous system

Frequency not reported: Drowsiness, confusion, headache, tinnitus[Ref]

Hypersensitivity

Aspirin:

Frequency not reported: Bronchospasm and asthma attacks or other hypersensitivity reactions including urticaria, rhinitis and angioneurotic edema in susceptible individuals[Ref]

Other

Aspirin:

Frequency not reported: Reye's syndrome

Codeine:

Frequency not reported: Vertigo[Ref]

Cardiovascular

Frequency not reported: Hypotension, bradycardia, tachycardia, palpitations[Ref]

Dermatologic

Frequency not reported: Sweating, pruritus, angioedema, urticaria and other skin eruptions[Ref]

Renal

Aspirin:

Frequency not reported: Deterioration in renal function[Ref]

Hematologic

Aspirin:

Frequency not reported: Increased bleeding time, anemia, hemolytic anemia, hypoprothrombinemia, thrombocytopenia, aplastic anemia, pancytopenia[Ref]

Hepatic

Frequency not reported: Hepatitis, hepatotoxicity[Ref]

Metabolic

Frequency not reported: Dehydration, hyperkalemia, respiratory alkalosis and metabolic acidosis, (particularly during salicylate toxicity), hypoglycemia[Ref]

Musculoskeletal

Aspirin:

Frequency not reported: Rhabdomyolysis[Ref]

Respiratory

Aspirin:

Frequency not reported: Hyperpnea, pulmonary edema, tachypnea, bronchospasm

Codeine:

Frequency not reported: Respiratory depression[Ref]

Ocular

Frequency not reported: Miosis, blurred or double vision[Ref]

Psychiatric

Codeine:

Frequency not reported: Confusion, mood changes, depression, trouble sleeping, withdrawal symptoms following regular prolonged use (restlessness irritability)[Ref]

Genitourinary

Codeine:

Frequency not reported: Ureteral spasm

References

1. Petty GW, Brown RD, Whisnant JP, Sicks JD, O'Fallon WM, Wiebers DO "Frequency of major complications of aspirin, warfarin, and intravenous heparin for secondary stroke prevention: a population study." Ann Intern Med 130 (1999): 14-22

2. "Multum Information Services, Inc. Expert Review Panel"

3. Lanas A, Serrano P, Bajador E, Esteva F, Benito R, Sainz R "Evidence of aspirin use in both upper and lower gastrointestinal perforation." Gastroenterology 112 (1997): 683-9

4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

5. Cerner Multum, Inc. "Australian Product Information." O 0

6. "Product Information. Calcidrine (codeine)." Abbott Pharmaceutical, Abbott Park, IL.

7. Gonzalogarijo MA, Revengaarranz F "Fixed drug eruption due to codeine." Br J Dermatol 135 (1996): 498-9

8. Hill SA, Quinn K, Shelly MP, Park GR "Reversible renal failure following opioid administration." Anaesthesia 46 (1991): 938-9

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.