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Aprocitentan Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 10, 2025.

Applies to aprocitentan: oral tablets film-coated.

Important warnings This medicine can cause some serious health issues

    Fetal/Neonatal Morbidity and Mortality
  • Based on animal data, may cause fetal harm during pregnancy.1

  • Exclude pregnancy in females of childbearing potential prior to treatment initiation and prevent thereafter by using acceptable methods of contraception during and for 1 month after discontinuation of therapy.1

  • When pregnancy is detected, discontinue aprocitentan as soon as possible.1

Side effects include:

Adverse effects reported in ≥2% of patients receiving aprocitentan include edema/fluid retention and anemia.

For healthcare professionals

Applies to aprocitentan: oral tablet.

General adverse events

The most frequently reported side effects included anemia, edema, and fluid retention.[Ref]

Dermatologic

Hematologic

Hepatic

Hypersensitivity

Hypersensitivity included rash, erythema, and allergic edema.

Metabolic

Renal

References

1. (2024) "Product Information. Tryvio (aprocitentan)." Idorsia Pharmaceuticals US Inc.

Does Aprocitentan interact with my other drugs?

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Further information

Aprocitentan side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.