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Altretamine Side Effects

In Summary

Commonly reported side effects of altretamine include: peripheral neuropathy, anemia, and nausea and vomiting. Other side effects include: leukopenia, and thrombocytopenia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to altretamine: oral capsule

Along with its needed effects, altretamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur while taking altretamine:

Less Common or Rare

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness, accompanied by fever or chills
  • fever or chills
  • lower back or side pain, accompanied by fever or chills
  • painful or difficult urination, accompanied by fever or chills
  • pinpoint red spots on skin
  • unusual bleeding or bruising
  • unusual tiredness

Check with your doctor as soon as possible if any of the following side effects occur while taking altretamine:

More Common

Rare

Some side effects of altretamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Less Common

  • Diarrhea
  • loss of appetite
  • stomach cramps

For Healthcare Professionals

Applies to altretamine: oral capsule

Hematologic

Very common (10% or more): Anemia (33%)

Common (1% to 10%): Thrombocytopenia, leukopenia[Ref]

Gastrointestinal

Very common (10% or more): Nausea and vomiting (33%)

Common (1% to 10%): Increased alkaline phosphatase[Ref]

Nervous system

Very common (10% or more): Peripheral sensory neuropathy (31%)

Common (1% to 10%): Seizures

Frequency not reported: CNS symptoms (mood disorders, disorders of consciousness, ataxia, dizziness, vertigo)[Ref]

Renal

Common (1% to 10%): Increased BUN, increased serum creatinine[Ref]

Metabolic

Uncommon (0.1% to 1%): Anorexia[Ref]

Other

Uncommon (0.1% to 1%): Fatigue[Ref]

Hepatic

Frequency not reported: Hepatic toxicity[Ref]

Dermatologic

Frequency not reported: Skin rash, pruritus, alopecia[Ref]

References

1. "Product Information. Hexalen Capsules (altretamine)." US Bioscience, West Conshohoken, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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