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Altretamine Side Effects

Medically reviewed by Last updated on Sep 17, 2022.


Commonly reported side effects of altretamine include: peripheral neuropathy, anemia, and nausea and vomiting. Other side effects include: leukopenia, and thrombocytopenia. Continue reading for a comprehensive list of adverse effects.

Applies to altretamine: oral capsules.


    Experience of Supervising Clinician
  • Use only under the supervision of a clinician experienced in therapy with antineoplastic agents.1

    Dose-Related Toxicities
  • Monitor peripheral blood counts at least monthly, prior to initiation of each course of therapy, and as clinically indicated.1

  • Risk of neurotoxicity.1 Perform neurologic examinations regularly during therapy.1

Side effects include:

Nausea, vomiting, peripheral sensory neuropathy, leukopenia, thrombocytopenia, anemia, increased serum alkaline phosphatase, increased serum creatinine/BUN.

For Healthcare Professionals

Applies to altretamine: oral capsule.


Very common (10% or more): Anemia (33%)

Common (1% to 10%): Thrombocytopenia, leukopenia[Ref]


Very common (10% or more): Nausea and vomiting (33%)

Common (1% to 10%): Increased alkaline phosphatase[Ref]

Nervous system

Very common (10% or more): Peripheral sensory neuropathy (31%)

Common (1% to 10%): Seizures

Frequency not reported: CNS symptoms (mood disorders, disorders of consciousness, ataxia, dizziness, vertigo)[Ref]


Common (1% to 10%): Increased BUN, increased serum creatinine[Ref]


Uncommon (0.1% to 1%): Anorexia[Ref]


Uncommon (0.1% to 1%): Fatigue[Ref]


Frequency not reported: Hepatic toxicity[Ref]


Frequency not reported: Skin rash, pruritus, alopecia[Ref]


1. "Product Information. Hexalen (altretamine)." US Bioscience (2022):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.