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Altretamine Dosage

Applies to the following strengths: 50 mg

Usual Adult Dose for Ovarian Cancer

260 mg/m2/day orally given in 4 divided doses after meals and at bedtime, either for 14 or 21 consecutive days in a 28-day cycle.

Comments: There is no pharmacokinetic information supporting this dosing regimen and the effect of food on bioavailability and pharmacokinetics has not been evaluated.

Use: Indicated as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

GI Intolerance Unresponsive to Symptomatic Measures; White Blood Count Less Than 2,000/mm3 or Granulocyte Count Less Than 1,000/mm3; Platelet Count Less Than 75,000/mm3; and/or Progressive Neurotoxicity:

Precautions

US BOXED WARNING:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration Advice:


Storage Requirements:

General:

Monitoring:

More about altretamine

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.