Altretamine Dosage
Applies to the following strengths: 50 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Ovarian Cancer
260 mg/m2/day orally given in 4 divided doses after meals and at bedtime, either for 14 or 21 consecutive days in a 28-day cycle.
Comments: There is no pharmacokinetic information supporting this dosing regimen and the effect of food on bioavailability and pharmacokinetics has not been evaluated.
Use: Indicated as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
GI Intolerance Unresponsive to Symptomatic Measures; White Blood Count Less Than 2,000/mm3 or Granulocyte Count Less Than 1,000/mm3; Platelet Count Less Than 75,000/mm3; and/or Progressive Neurotoxicity:
- Temporarily discontinue treatment for 14 days or longer and subsequently restart dose at 200 mg/m2/day.
- Discontinue treatment indefinitely if neurological symptoms fail to stabilize on the reduced dose schedule.
Precautions
US BOXED WARNING:
- This drug should only be given under the supervision of a physician experienced in the use of antineoplastic agents.
- Peripheral blood counts should be monitored at least monthly, prior to the initiation of each treatment course and as clinical indicated.
- Neurological examination should be performed regularly during treatment because of the possibility of drug-related neurotoxicity.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration Advice:
- Preparation, handling, and disposal of this drug should be performed in a manner consistent with safe procedures for cytotoxic agents.
Storage Requirements:
- This drug should be stored up to 25 degrees Celsius (77 Fahrenheit).
General:
- This drug has been efficacious for certain ovarian tumors resistant to classical alkylating agents.
- This drug is practically insoluble in water but is increasingly soluble at pH3 and below.
Monitoring:
- Hematological: Peripheral blood counts
- Nervous System: Neurological examination
More about altretamine
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- During pregnancy
- Drug class: miscellaneous antineoplastics
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Further information
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