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Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels Side Effects

Generic name: acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine

Medically reviewed by Drugs.com. Last updated on Jun 6, 2024.

Note: This document provides detailed information about Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels Side Effects associated with acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine. Some dosage forms listed on this page may not apply specifically to the brand name Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels.

Applies to acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine: oral capsule, oral liquid, oral tablet, oral tablet chewable.

Important warnings This medicine can cause some serious health issues

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

An acetaminophen overdose can damage your liver or cause death. Call your doctor at once if you have stomach pain (upper right side), loss of appetite, tiredness, itching, dark urine, clay-colored stools, or yellowing of your skin or eyes.

Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Do not use this medicine only to make a child sleepy.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using this medicine and call your doctor at once if you have:

Some side effects may be more likely in older adults.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

More about Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels (acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine)

Patient resources

Other brands

Tylenol Cold, Comtrex Cold and Flu Maximum Strength Tablet, Childrens Tylenol Cold Plus Cough, Theracaps Multi-Symptom Cough & Cold Reliever

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Further information

Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.