Acetaminophen / Chlorpheniramine / Dextromethorphan / Pseudoephedrine Dosage
Medically reviewed by Drugs.com. Last updated on Jul 9, 2025.
Applies to the following strengths: 160 mg-1 mg-5 mg-15 mg/5 mL; 500 mg-4 mg-20 mg-60 mg/15 mL; 1000 mg-4 mg-30 mg-60 mg; 650 mg-4 mg-20 mg-60 mg; 80 mg-0.5 mg-2.5 mg-7.5 mg; 650 mg-4 mg-30 mg-60 mg; 160 mg-1 mg-7.5 mg-15 mg/5 mL; 1000 mg-4 mg-30 mg-60 mg/30 mL; 500 mg-2 mg-15 mg-30 mg; 650 mg-4 mg-30 mg-60 mg/20 mL; 325 mg-2 mg-15 mg-30 mg; 325 mg-2 mg-10 mg-30 mg; varying strength
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Cold Symptoms
acetaminophen/chlorpheniramine/dextromethorphan/PSE varying strength oral kit:
Day time tablets (without chlorpheniramine): 2 tablets every 6 hours during waking hours as needed.
Night time tablets: 2 tablets every 6 hours during sleeping hours as needed.
Not to exceed a total of 8 tablets/day of day and night tablets combined.
Usual Adult Dose for Influenza
acetaminophen/chlorpheniramine/dextromethorphan/PSE varying strength oral kit:
Day time tablets (without chlorpheniramine): 2 tablets every 6 hours during waking hours as needed.
Night time tablets: 2 tablets every 6 hours during sleeping hours as needed.
Not to exceed a total of 8 tablets/day of day and night tablets combined.
Usual Pediatric Dose for Cold Symptoms
acetaminophen/chlorpheniramine/dextromethorphan/PSE varying strength oral kit:
12 yrs and older: Day time tablets (without chlorpheniramine): 2 tablets every 6 hours during waking hours as needed.
Night time tablets: 2 tablets every 6 hours during sleeping hours as needed.
Not to exceed a total of 8 tablets/day of day and night tablets combined.
Usual Pediatric Dose for Influenza
acetaminophen/chlorpheniramine/dextromethorphan/PSE varying strength oral kit:
12 yrs and older: Day time tablets (without chlorpheniramine): 2 tablets every 6 hours during waking hours as needed.
Night time tablets: 2 tablets every 6 hours during sleeping hours as needed.
Not to exceed a total of 8 tablets/day of day and night tablets combined.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
The FDA has not approved use of over-the-counter cough and cold medications to children aged less than 2 years, and proper dosing for children in this age group has not been studied. Clinicians should be aware of the risk for serious illness or fatal overdose from administration of cough and cold medications to children aged less than 2 years. Clinicians should be certain that caregivers understand 1) the importance of administering cough and cold medications only as directed and 2) the risk for overdose if they administer additional medications that might contain the same ingredient.
Dialysis
Data not available
More about acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine
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- Drug class: upper respiratory combinations
Patient resources
Other brands
Comtrex Cold and Flu Maximum Strength Tablet, Theracaps Multi-Symptom Cough & Cold Reliever
Related treatment guides
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
