Skip to Content

Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets Side Effects

Generic Name: aspirin / chlorpheniramine / phenylephrine

Note: This document contains side effect information about aspirin / chlorpheniramine / phenylephrine. Some of the dosage forms listed on this page may not apply to the brand name Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets.

Applies to aspirin / chlorpheniramine / phenylephrine: oral tablet effervescent

Get emergency medical help if you have any of these signs of an allergic reaction while taking aspirin / chlorpheniramine / phenylephrine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • chest pain, rapid pulse, fast or uneven heart rate;

  • ringing in your ears, severe headache, confusion, hallucinations, severe nervousness, feeling like you might pass out;

  • tremor, seizure (convulsions);

  • feeling short of breath, little or no urinating;

  • redness or swelling, new cold or flu symptoms;

  • easy bruising or bleeding, unusual weakness; or

  • dangerously high blood pressure (severe headache, buzzing in your ears, anxiety, shortness of breath).

Common side effects may include:

  • dizziness, drowsiness, blurred vision;

  • dry mouth, nose, or throat;

  • heartburn, nausea, diarrhea, constipation, upset stomach;

  • feeling nervous, restless, or irritable; or

  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.