Acyclovir Side Effects
More frequently reported side effects include: nausea, phlebitis, vomiting, and inflammation at injection site. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to acyclovir: buccal mucosa tablet
Other dosage forms:
Along with its needed effects, acyclovir may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking acyclovir:
- Canker sores
- pain in the gums
- sores, ulcers, or white spots on the tongue or inside the mouth
Some side effects of acyclovir may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Flushing or redness of the skin
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- unusually warm skin
For Healthcare Professionals
Applies to acyclovir: buccal tablet, compounding powder, intravenous powder for injection, intravenous solution, oral capsule, oral suspension, oral tablet
The more commonly reported adverse reactions include malaise, nausea, vomiting, diarrhea, and headache.[Ref]
Uncommon (0.1% to 1%): Sore throat
Postmarketing reports: Gastrointestinal distress[Ref]
Rare (0.01% to 0.1%): Elevated blood urea nitrogen, elevated creatinine,
Very rare (less than 0.01%): Acute renal failure, renal pain
Frequency not reported: Crystalluria, renal impairment
Renal pain may be associated with renal failure and crystalluria. Renal impairment is generally reversible but may progress to acute renal failure.[Ref]
Common (1% to 10%): Application site pain and application site irritation, local inflammation at injection site, phlebitis
Frequency not reported: Tissue necrosis[Ref]
Severe local inflammatory reactions, including tissue necrosis, have occurred following infusion into extravascular tissues. Application site pain and application site irritation have occurred with the buccal tablets.[Ref]
Dizziness, somnolence, and coma more frequent in elderly subjects.[Ref]
Common (1% to 10%): Headache, dizziness
Very rare (less than 0.01%): Ataxia, coma, convulsions, encephalopathy, dysarthria
Frequency not reported: Giddiness, shaking, taste disturbance, medication taste
Postmarketing reports: Decreased consciousness, delirium, paresthesia, seizure, tremors[Ref]
Frequency not reported: Diaphoresis
Frequency not reported: Palpitation, chest pain
Frequency not reported: Hematologic changes including megaloblastic anemia
Rare (0.01% to 0.1%): Reversible bilirubin and liver related enzymes
Very rare (less than 0.01%): Hepatitis, jaundice
Rare (0.01% to 0.1%): Anaphylaxis
Frequency not reported: Pars planitis
Postmarketing reports: Visual abnormalities[Ref]
Uncommon (0.1% to 1%): Leg pain
Postmarketing reports: Myalgia[Ref]
Common (1% to 10%): Lethargy, fatigue, fever
Frequency not reported: Vertigo
Postmarketing reports: Fever[Ref]
Uncommon (0.1% to 1%): Anorexia
Frequency not reported: Thirst[Ref]
Very rare (less than 0.01%): Agitation, confusion, hallucinations, psychotic symptoms
Postmarketing reports: Aggressive behavior[Ref]
1. "Product Information. Acyclovir (acyclovir)." West-Ward Pharmaceuticals Corporation (previously Roxane Laboratories Inc), Columbus, OH.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
4. "Product Information. Sitavig (acyclovir)." Innocutis Holdings LLC, Charleston, SC.
5. "Product Information. Zovirax (acyclovir)." Mylan Pharmaceuticals Inc, Morgantown, WV.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
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