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Nystatin (Topical)

Medically reviewed by Drugs.com. Last updated on June 9, 2020.

Pronunciation

(nye STAT in)

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Cream, External:

Generic: 100,000 units/g (15 g, 30 g)

Ointment, External:

Generic: 100,000 units/g (15 g, 30 g)

Powder, External:

Nyamyc: 100,000 units/g (15 g, 30 g, 60 g)

Nyata: 100,000 units/g (45 g [DSC])

Nystop: 100,000 units/g (15 g, 30 g, 60 g)

Generic: 100,000 units/g (15 g, 30 g, 60 g)

Brand Names: U.S.

  • Nyamyc
  • Nyata [DSC]
  • Nystop

Pharmacologic Category

  • Antifungal Agent, Topical

Pharmacology

Binds to sterols in fungal cell membrane, changing the cell wall permeability allowing for leakage of cellular contents

Absorption

None through mucous membranes or intact skin

Onset of Action

Symptomatic relief from candidiasis: 24 to 72 hours

Use: Labeled Indications

Fungal infections (cutaneous and mucocutaneous): Treatment of cutaneous and mucocutaneous fungal infections caused by Candida albicans and other susceptible Candida species.

Contraindications

Hypersensitivity to nystatin or any component of the formulation

Dosing: Adult

Fungal infections (cutaneous and mucocutaneous): Topical: Note: Cream is usually preferred to ointment for intertriginous areas; very moist lesions are best treated with topical powder

Cream, ointment: Apply to the affected areas twice daily or as indicated until healing is complete

Powder: Apply to the affected areas 2 to 3 times daily until healing is complete

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Diaper dermatitis, candidal: Limited data available: Infants: Ointment, cream: Topical: Apply 2 to 4 times daily to affected area; most studies have used 4 times daily dosing (Hoppe, 1997; Munz 1982)

Mucocutaneous candidal infections: Infants, Children, and Adolescents:

Manufacturer's labeling:

Cream/ointment: Topical: Apply to affected area twice daily

Powder: Topical: Apply to affected area 2 to 3 times daily

Alternate dosing: Limited data available: Cream, ointment, powder: Topical: Apply to affected area 2 to 4 times daily (Bradley 2015)

Administration

For topical external use only; not for systemic, oral, intravaginal, or ophthalmic use. Apply liberally to clean/dry skin. For fungal infection of the feet, the powder should be dusted in all footwear (in addition to application to the feet).

Storage

Cream, ointment: Store at room temperature.

Topical powder: Store between 15°C to 30°C (59°F to 86°F). Avoid excessive heat (40°C [104°F]).

Drug Interactions

Progesterone: Antifungal Agents (Vaginal) may diminish the therapeutic effect of Progesterone. Avoid combination

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined: Dermatologic: Contact dermatitis, Stevens-Johnson syndrome

<1%, postmarketing, and/or case reports: Hypersensitivity reaction

Warnings/Precautions

Concerns related to adverse effects:

• Hypersensitivity: May occur; immediately discontinue if signs of a hypersensitivity reaction occur.

• Irritation: Discontinue if irritation occurs.

Other warnings/precautions:

• Appropriate use: For topical external use only; not for systemic, oral, intravaginal, or ophthalmic use.

Pregnancy Risk Factor

C

Pregnancy Considerations

Animal reproduction studies have not been conducted. Absorption following oral use is poor and nystatin is not absorbed following application to mucous membranes or intact skin.

Patient Education

What is this drug used for?

• It is used to treat fungal infections of the skin.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Severe skin irritation

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.