Medically reviewed by Drugs.com. Last updated on Jun 24, 2019.
(nye STAT in)
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Generic: 100,000 units/g (15 g, 30 g)
Nyata: 100,000 units/g [DSC]
Pediaderm AF Complete: 100,000 units/g [DSC] [contains methylparaben, propylene glycol, propylparaben]
Generic: 100,000 units/g (15 g, 30 g)
Nyamyc: 100,000 units/g (15 g, 30 g, 60 g)
Nyata: 100,000 units/g (45 g [DSC])
Nystop: 100,000 units/g (15 g, 30 g, 60 g)
Generic: 100,000 units/g (15 g, 30 g, 60 g)
Brand Names: U.S.
- Nyata [DSC]
- Pediaderm AF Complete [DSC]
- Antifungal Agent, Topical
Binds to sterols in fungal cell membrane, changing the cell wall permeability allowing for leakage of cellular contents
None through mucous membranes or intact skin
Onset of Action
Symptomatic relief from candidiasis: 24 to 72 hours
Use: Labeled Indications
Fungal infections (cutaneous and mucocutaneous): Treatment of cutaneous and mucocutaneous fungal infections caused by Candida albicans and other susceptible Candida species.
Hypersensitivity to nystatin or any component of the formulation
Fungal infections (cutaneous and mucocutaneous): Topical: Note: Cream is usually preferred to ointment for intertriginous areas; very moist lesions are best treated with topical powder
Cream, ointment: Apply to the affected areas twice daily or as indicated until healing is complete
Powder: Apply to the affected areas 2 to 3 times daily until healing is complete
Refer to adult dosing.
Diaper dermatitis, candidal: Limited data available: Infants: Ointment, cream: Topical: Apply 2 to 4 times daily to affected area; most studies have used 4 times daily dosing (Hoppe, 1997; Munz 1982)
Mucocutaneous candidal infections: Infants, Children, and Adolescents:
Cream/ointment: Topical: Apply to affected area twice daily
Powder: Topical: Apply to affected area 2 to 3 times daily
Alternate dosing: Limited data available: Cream, ointment, powder: Topical: Apply to affected area 2 to 4 times daily (Bradley 2015)
For topical external use only; not for systemic, oral, intravaginal, or ophthalmic use. Apply liberally to clean/dry skin. For fungal infection of the feet, the powder should be dusted in all footwear (in addition to application to the feet).
Cream, ointment: Store at room temperature.
Topical powder: Store between 15°C to 30°C (59°F to 86°F). Avoid excessive heat (40°C [104°F]).
Progesterone: Antifungal Agents (Vaginal) may diminish the therapeutic effect of Progesterone. Avoid combination
Frequency not defined: Dermatologic: Contact dermatitis, Stevens-Johnson syndrome
<1%, postmarketing, and/or case reports: Hypersensitivity reaction
Concerns related to adverse effects:
• Hypersensitivity: May occur; immediately discontinue if signs of a hypersensitivity reaction occur.
• Irritation: Discontinue if irritation occurs.
• Appropriate use: For topical external use only; not for systemic, oral, intravaginal, or ophthalmic use.
Pregnancy Risk Factor
Animal reproduction studies have not been conducted. Absorption following oral use is poor and nystatin is not absorbed following application to mucous membranes or intact skin.
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Have patient report immediately to prescriber severe skin irritation (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.
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- Drug class: topical antifungals