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Medically reviewed by Last updated on Nov 7, 2023.


(KOP er)

Index Terms

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral [preservative free]:

Cu-5: 5 mg [dye free]

Solution, Intravenous:

Generic: 0.4 mg/mL (10 mL)

Tablet, Oral:

Coppermin: 5 mg [corn free, rye free, wheat free]

Brand Names: U.S.

Pharmacologic Category


Copper is an essential nutrient which serves as a cofactor for serum ceruloplasmin, an oxidase necessary for proper formation of the iron carrier protein, transferrin. It also helps maintain normal rates of red and white blood cell formation and helps prevent development of deficiency symptoms: Leukopenia, neutropenia, anemia, depressed ceruloplasmin levels, impaired transferring formation, secondary iron deficiency and osteoporosis.


Bile (primarily, 80%); intestinal wall (16%); urine (4%)

Use: Labeled Indications

Trace element added to parenteral nutrition (PN) to prevent copper deficiency; orally as a dietary supplement


There are no contraindications listed in the manufacturer's labeling.

Dosing: Adult

Parenteral nutrition additive, maintenance requirement (ASPEN [Vanek 2012]): IV: 0.3 to 0.5 mg/day

High output intestinal fistula: Some clinicians may use twice the recommended daily allowance (ASPEN 2002)

Dosing: Geriatric

Use caution. Start at the low end of dosing range.

Dosing: Pediatric

Parenteral nutrition additive, maintenance requirement (ASPEN [Corkins 2015]; ASPEN [Mirtallo 2004]; ASPEN [Vanek 2012]): Note: Higher doses may be needed in patients with deficiency and increased requirements. IV:

Infants <10 kg: 20 mcg/kg/day

Infants and Children weighing 10 to 40 kg: 5 to 20 mcg/kg/day; maximum daily dose: 500 mcg/day

Children and Adolescents weighing >40 kg: 200 to 500 mcg/day


IV: Must dilute in a volume ≥100 mL.


IV: Must be diluted. Do not administer IM or by direct IV injection; acidic pH of the solution may cause tissue irritation.

Dietary Considerations

Dietary adequate intake (AI) (IOM 2001):

1 to 6 months of age: 200 mcg/day (~30 mcg/kg/day)

7 to 12 months of age: 220 mg/day (~24 mcg/kg/day)

Dietary recommended daily allowances (RDA) (IOM 2001):

1 to 3 years of age: 340 mcg/day

4 to 8 years of age: 440 mcg/day

9 to 13 years of age: 700 mcg/day

14 to 18 years of age: 890 mcg/day

>18 years: 900 mcg/day

Pregnancy: 1,000 mcg/day

Lactation: 1,300 mcg/day


Store at controlled room temperature of 20°C to 25°C (68°F to 77°F).

Drug Interactions

Ascorbic Acid: Copper may decrease the serum concentration of Ascorbic Acid. Management: To minimize the risk for ascorbic acid degradation, add multivitamin product to TPN solution immediately prior to infusion or administer multivitamin and copper in separate containers. Consider therapy modification

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Generally well tolerated; excessive copper levels may result in the following adverse effect.

Hepatic: Hepatic insufficiency (including hepatic necrosis)


Disease-related concerns:

• Gastrointestinal fistulae: Patients with high output intestinal fistulae may require a larger dose than the recommended daily allowance (ASPEN, 2002).

• Hepatic impairment: Use with caution in patients with hepatic impairment (eg, impaired biliary excretion or cholestatic liver disease).

• Wilson's disease: Administration not recommended.

Concurrent drug therapy issues:

• TPN preparation: Copper ion may degrade ascorbic acid in TPN solutions. To avoid loss, add multivitamin additives to TPN solutions immediately prior to infusion or add to separate TPN solution container.

Dosage form specific issues:

• Aluminum: The parenteral product may contain aluminum; toxic aluminum concentrations may be seen with high doses, prolonged use, or renal dysfunction. Premature neonates are at higher risk due to immature renal function and aluminum intake from other parenteral sources. Parenteral aluminum exposure of >4 to 5 mcg/kg/day is associated with CNS and bone toxicity; tissue loading may occur at lower doses (Federal Register, 2002). See manufacturer's labeling.

Monitoring Parameters

Copper and/or ceruloplasmin serum concentrations in long-term parenteral nutrition patients (twice monthly) and patients with burns, cholestasis, hepatic failure, or high output gastrointestinal fistulas (ASPEN [Vanek 2012])

Pregnancy Considerations

Animal reproduction studies have not been conducted.

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