(bas i TRAY sin)
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Generic: 500 units/g (1 g [DSC], 3.5 g)
- Antibiotic, Ophthalmic
Inhibits bacterial cell wall synthesis by preventing transfer of mucopeptides into the growing cell wall
Use: Labeled Indications
Superficial ocular infections: Treatment of superficial ocular infections involving the conjunctiva or cornea due to susceptible organisms
Hypersensitivity to bacitracin or any component of the formulation
Ophthalmic infection: Ophthalmic: Apply 1 to 3 times daily
Refer to adult dosing.
Ophthalmic infection: Children and Adolescents: Ophthalmic: Refer to adult dosing.
Ophthalmic: For topical ophthalmic use only; apply directly into conjunctival sac. For blepharitis, after carefully removing all scales and crusts, apply uniformly over lid margins. Avoid gross contamination of ointment during application.
Store at 20°C to 25°C (68°F to 77°F).
There are no known significant interactions.
1% to 10%: Hypersensitivity: Hypersensitivity reaction (7% [Hätinen, 1985])
Postmarketing and/or case reports: Contact dermatitis (Pichichero, 2011)
Concerns related to adverse effects:
• Bacterial overgrowth: Prolonged use may result in overgrowth of nonsusceptble organisms, particularly fungi; if new infection develops, initiate appropriate therapy.
• Hypersensitivity/anaphylaxis: Use with caution in patients who have been previously exposed to bacitracin; anaphylactic reactions have occurred on repeat exposure (Elsner, 1990; Farley, 1995).
• Appropriate use: Should not be used in deep seated ocular infections or if infection is likely to become systemic.
Bacitracin is not absorbed systemically following ophthalmic administration (Robert, 2001). If ophthalmic agents are needed during pregnancy, the minimum effective dose should be used in combination with punctual occlusion to decrease potential exposure to the fetus (Samples, 1988).
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.
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