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Bacitracin, Neomycin, and Polymyxin B (Topical)

Medically reviewed by Last updated on July 19, 2020.


(bas i TRAY sin, nee oh MYE sin, & pol i MIKS in bee)

Index Terms

  • Neomycin, Bacitracin, and Polymyxin B
  • Polymyxin B, Bacitracin, and Neomycin
  • Triple Antibiotic

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Ointment, External:

Curad Triple Antibiotic: bacitracin, neomycin, and polymyxin B (1 ea)

Medi-First Triple Antibiotic: bacitracin, neomycin, and polymyxin B (1 ea)

Neosporin Original: bacitracin, neomycin, and polymyxin B (1 ea, 14.2 g, 28.3 g)

Triple Antibiotic: bacitracin, neomycin, and polymyxin B (1 ea, 1 g, 9.4 g, 14 g, 14.2 g, 15 g, 28 g, 28.4 g, 30 g, 453.9 g)

Triple Antibiotic First Aid: bacitracin, neomycin, and polymyxin B (1 ea [DSC])

Generic: bacitracin, neomycin, and polymyxin B (1 ea [DSC], 14.17 g [DSC], 28.35 g [DSC])

Brand Names: U.S.

  • Curad Triple Antibiotic [OTC]
  • Medi-First Triple Antibiotic [OTC]
  • Neosporin Original [OTC]
  • Triple Antibiotic First Aid [OTC] [DSC]
  • Triple Antibiotic [OTC]

Pharmacologic Category

  • Antibiotic, Topical


See individual agents.

Use: Labeled Indications

Topical infection prevention: Prevention of infection in minor cuts, scrapes, or burns.


Hypersensitivity to bacitracin, neomycin, polymyxin B, or any component of the formulation.

Dosing: Adult

Topical infection prevention: Topical: Apply 1 to 3 times/day to infected area; may cover with sterile bandage if necessary.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Prevention of infection: Infants, Children, and Adolescents: Topical: Apply to affected area 1 to 3 times daily


Topical: For external use only. Clean affected area prior to application. Apply amount equal to the surface area of the tip of the finger. Do not use topical ointment in the eyes or over large areas of the body; avoid contact of tube tip with skin.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.

Dermatologic: Reddening, allergic contact dermatitis

Local: Itching, failure to heal, swelling, irritation

Miscellaneous: Anaphylaxis


Dosage form specific issues:

• Topical ointment: When used for self-medication (OTC use), patients should notify healthcare provider if needed for >1 week. Should not be used for self-medication on deep or puncture wounds, animal bites, or serious burns. Not for application to large areas of the body.

Pregnancy Risk Factor


Pregnancy Considerations

Animal reproduction studies have not been conducted with this combination.

Patient Education

What is this drug used for?

• It is used to avoid or treat skin infections.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Redness

• Itching

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Swelling

• Severe skin irritation

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.