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Bacitracin and Polymyxin B (Topical)

Medically reviewed by Last updated on Sep 7, 2020.


(bas i TRAY sin & pol i MIKS in bee)

Index Terms

  • Bacitracin Zinc/Polymyx B Sulfate
  • Bacitracin/Polymyxin B Sulfate
  • Polymyxin B and Bacitracin

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Ointment, External:

Double Antibiotic: Bacitracin 500 units and polymyxin B 10,000 units per g (1 ea, 14 g, 14.17 g, 28 g, 28.35 g, 28.4 g)

Polysporin: Bacitracin 500 units and polymyxin B 10,000 units per g (1 ea, 14.2 g, 28.3 g)

Brand Names: U.S.

  • Double Antibiotic [OTC]
  • Polysporin [OTC]

Pharmacologic Category

  • Antibiotic, Topical


See individual agents.


Insignificant from intact skin or mucous membrane

Use: Labeled Indications

Topical infection prevention: Prevention of infection in minor cuts, scrapes, or burns


Hypersensitivity to bacitracin, polymyxin B, or any component of the formulation

Dosing: Adult

Topical infection prevention: Topical: Apply to affected area 1 to 3 times/day; may cover with sterile bandage if needed.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Prevention of infection: Infants, Children, and Adolescents: Topical ointment: Apply to the affected area 1 to 3 times daily; may cover with sterile bandage if needed


Topical: Clean affected area prior to application. Apply amount equal to the surface area of the tip of the finger. Do not use topical ointment in the eyes or over large areas of the body; avoid contact of tube tip with skin.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

See individual agents.

Pregnancy Risk Factor C Pregnancy Considerations

Refer to individual monographs.

Patient Education

What is this drug used for?

• It is used to avoid or treat skin infections.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.