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Bacitracin and Polymyxin B (Topical)


(bas i TRAY sin & pol i MIKS in bee)

Index Terms

  • Bacitracin Zinc/Polymyx B Sulfate
  • Bacitracin/Polymyxin B Sulfate
  • Polymyxin B and Bacitracin

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Ointment, External:

Double Antibiotic: 500-10000 UNIT/GM (1 ea, 14.17 g, 28.35 g)

Polysporin: 500-10000 UNIT/GM (1 ea, 14.2 g, 28.3 g)

Brand Names: U.S.

  • Double Antibiotic [OTC]
  • Polysporin [OTC]

Pharmacologic Category

  • Antibiotic, Topical


See individual agents.


Insignificant from intact skin or mucous membrane

Use: Labeled Indications

Topical infection prevention: Prevention of infection in minor cuts, scrapes, or burns


Hypersensitivity to bacitracin, polymyxin B, or any component of the formulation

Dosing: Adult

Topical infection prevention: Topical: Apply to affected area 1 to 3 times/day; may cover with sterile bandage if needed.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Topical infection prevention: Children and Adolescents: Refer to adult dosing.


Topical: Do not use topical ointment in the eyes; avoid contact of tube tip with skin.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

See individual agents.

Pregnancy Risk Factor


Pregnancy Considerations

Animal reproduction studies have not been conducted with this combination.

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience burning or itching. Have patient report immediately to prescriber edema or severe skin irritation (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

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