Generic Name: choline magnesium trisalicylate (KOE leen mag NEE see um TRYE sa LIS i late)
Brand Name: Choline Magnesium Trisalicylate, Tricosal, Trilisate
What is Trilisate (choline magnesium trisalicylate)?
Choline magnesium trisalicylate is a non-steroidal anti-inflammatory drug (NSAID) that contains a combination of choline salicylate and magnesium salicylate.
Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.
Choline magnesium trisalicylate may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Trilisate (choline magnesium trisalicylate)?
This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.
This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning, especially in older adults.
Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
This medication should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Salicylates can cause a serious and sometimes fatal condition called Reye's syndrome in children.
What should I discuss with my healthcare provider before taking Trilisate (choline magnesium trisalicylate)?
This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use choline magnesium trisalicylate just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
You should not use this medication if you are allergic to aspirin or to an NSAID, or if you have recently used cidofovir (Vistide), ketorolac (Toradol), or nasal flu vaccine (FluMist).
To make sure you can safely take this medicine, tell your doctor if you have any of these other conditions:
heart disease, high blood pressure, congestive heart failure, or a history of stroke or heart attack;
a stomach ulcer or intestinal bleeding;
a bleeding or blood clotting disorder;
anemia (a lack of red blood cells);
liver or kidney disease;
an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
asthma, nasal polyps; or
swelling or fluid retention, or if you are dehydrated.
FDA pregnancy category C. Salicylates and NSAIDs may be harmful to an unborn baby if the mother takes the medication during the last 3 months of pregnancy. Tell your doctor if you are pregnant or plan to become pregnant.
Choline magnesium trisalicylate can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not give to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Salicylates can cause a serious and sometimes fatal condition called Reye's syndrome in children.
How should I take Trilisate (choline magnesium trisalicylate)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Take choline magnesium trisalicylate with food, milk, or an antacid if it upsets your stomach. You may need to take the medicine at bedtime, at least 30 minutes before you lie down.
Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. You may mix the liquid with a small amount of fruit juice to make the medicine taste better. Stir the mixture well and drink all of it right away.
It may take up to 3 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 2 weeks of treatment.
This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using choline magnesium trisalicylate.
If you need surgery, tell the surgeon ahead of time that you are using choline magnesium trisalicylate. You may need to stop using the medicine for a short time.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include ringing in your ears, severe dizziness or drowsiness, confusion, or seizure (convulsions).
What should I avoid while taking Trilisate (choline magnesium trisalicylate)?
If you also take an antibiotic, avoid taking it within 2 hours before or after you take choline magnesium trisalicylate. This medication can make it harder for your body to absorb certain antibiotics.
If you are also taking low-dose aspirin to prevent heart attack or stroke, do not stop taking it or change your dose without your doctor's advice. Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.
Ask a doctor or pharmacist before using any cold, allergy, or pain medicine. Many medicines available over the counter contain salicylates or NSAIDs. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, naproxen, or a salicylate.
Drinking alcohol may increase your risk of stomach bleeding.
Smoking can also increase your risk of stomach bleeding.
Trilisate (choline magnesium trisalicylate) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using choline magnesium trisalicylate and call your doctor at once if you have a serious side effect such as:
chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
sudden numbness or weakness, especially on one side of the body;
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
blood in your urine, urinating more or less than usual;
hearing problems, ringing in your ears;
severe stomach pain, ongoing nausea or vomiting, jaundice (yellowing of the skin or eyes);
easy bruising or bleeding, unusual weakness; or
fast or pounding heartbeats, feeling like you might pass out.
Less serious side effects may include:
heartburn, upset stomach, diarrhea, constipation;
dizziness, drowsiness, lack of energy; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Trilisate (choline magnesium trisalicylate)?
Ask your doctor before taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with an NSAID may cause you to bruise or bleed easily.
Many drugs can interact with choline magnesium trisalicylate. Below is just a partial list. Tell your doctor if you are using:
cyclosporine (Gengraf, Neoral, Sandimmune);
lithium (Eskalith, LithoBid);
methotrexate (Rheumatrex, Trexall);
a blood thinner such as warfarin (Coumadin), or medication used to prevent blood clots, such as clopidogrel (Plavix);
diabetes medication you take by mouth;
a diuretic (water pill);
heart or blood pressure medication;
medicine to treat or prevent osteoporosis;
seizure medication such as phenytoin (Dilantin), phenobarbital (Solfoton), or valproic acid (Depakene);
medicines that contain sodium bicarbonate, sodium citrate, or potassium citrate; or
steroid medicine (prednisone and others).
This list is not complete and there are many other drugs that can interact with choline magnesium trisalicylate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
More about Trilisate (choline salicylate / magnesium salicylate)
- Side Effects
- Drug Images
- Drug Interactions
- Support Group
- En Español
- 1 Review – Add your own review/rating
- Drug class: salicylates
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about choline magnesium trisalicylate.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 8.02.
Date modified: July 24, 2017
Last reviewed: December 15, 2010