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Tikosyn

Generic Name: dofetilide (doe FET i lide)
Brand Name: Tikosyn

Medically reviewed: April 13, 2018

What is Tikosyn?

Tikosyn is a heart rhythm medicine, also called an antiarrhythmic.

Tikosyn is used to help keep the heart beating normally in people with certain heart rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart). This medicine is used in people with atrial fibrillation or atrial flutter.

Tikosyn may also be used for purposes not listed in this medication guide.

Important Information

You should not take Tikosyn if you have severe kidney disease or a history of Long QT syndrome.

Serious drug interactions can occur when certain medicines are used together with Tikosyn. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

You will need to spend at least 3 days in a hospital setting when you first start taking Tikosyn. This is so your heart rhythm and kidney function can be monitored in case the medicine causes serious side effects.

Before taking this medicine

You should not take Tikosyn if you are allergic to it, or if you have:

  • severe kidney disease (or if you are on dialysis); or

  • a history of Long QT syndrome.

Some medicines can cause unwanted or dangerous effects when used with Tikosyn, and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:

To make sure Tikosyn is safe for you, tell your doctor if you have:

  • heart disease, high blood pressure;

  • liver or kidney disease;

  • depression, mental illness;

  • asthma or allergies;

  • any active infection;

  • skin problems; or

  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether Tikosyn passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using this medicine.

How should I take Tikosyn?

Tikosyn is available only from a hospital or specialty pharmacy.

You will need to spend at least 3 days in a hospital setting when you first start taking Tikosyn. This is so your heart rhythm and kidney function can be monitored in case the medicine causes serious side effects.

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Tikosyn with or without food.

You should not skip doses or stop using Tikosyn suddenly. Stopping suddenly may make your condition worse. Follow your doctor's instructions about tapering your dose.

Tell your doctor if you have a prolonged illness that causes severe diarrhea, vomiting, or heavy sweating. These conditions can cause an electrolyte imbalance, making it dangerous for you to use Tikosyn.

Your blood pressure will need to be checked often. Your kidney function may also need to be checked with frequent blood tests.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Skip the missed dose and take your next dose at the usual time to stay on schedule. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Tikosyn?

Grapefruit and grapefruit juice may interact with Tikosyn and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

Tikosyn side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

  • loss of appetite, vomiting or severe diarrhea; or

  • low magnesium or potassium--confusion, uneven heart rate, increased thirst or urination, sweating, jerking muscle movements, leg discomfort, muscle weakness or limp feeling.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Tikosyn?

Other drugs may interact with dofetilide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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